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:: J. Biol. Chem. Table of Contents for 7 January 2011 ::

Journal of Biological Chemistry Table of Contents Alert
A new issue of Journal of Biological Chemistry is available online: 7 January 2011; Vol. 286, No. 1

The below Table of Contents is available online at: http://www.jbc.org/content/vol286/issue1/index.dtl?etoc

Papers of the Week

A Sprouty Stabilization: ErbB2 Stabilizes Epidermal Growth Factor Receptor (EGFR) Expression via Erk and Sprouty2 in Extracellular Matrix-detached Cells
J. Biol. Chem. 2011 286: e99901. First Published ; doi:10.1074/jbc.P110.169821 [Full Text] [PDF] [Author profile]  

A Bacteriophage Maturation: Molecular Rearrangements Involved in the Capsid Shell Maturation of Bacteriophage T7
J. Biol. Chem. 2011 286: e99902. First Published ; doi:10.1074/jbc.P110.187211 [Full Text] [PDF] [Author profile]  


Bioenergetics

Origin of Absorption Changes Associated with Photoprotective Energy Dissipation in the Absence of Zeaxanthin Cristian Ilioaia, Matthew P. Johnson, Christopher D. P. Duffy, Andrew A. Pascal, Rienk van Grondelle, Bruno Robert, and Alexander V. Ruban
J. Biol. Chem. 2011 286: 91-98. First Published on October 29, 2010; doi:10.1074/jbc.M110.184887 [Abstract] [Full Text] [PDF]  

Cox25 Teams Up with Mss51, Ssc1, and Cox14 to Regulate Mitochondrial Cytochrome c Oxidase Subunit 1 Expression and Assembly in Saccharomyces cerevisiae Flavia Fontanesi, Paula Clemente, and Antoni Barrientos
J. Biol. Chem. 2011 286: 555-566. First Published on November 10, 2010; doi:10.1074/jbc.M110.188805 [Abstract] [Full Text] [PDF] [Supplemental Figures (.pdf, 320 KB)]  


Cell Biology

 Role of MSK1 in the Malignant Phenotype of Ras-transformed Mouse Fibroblasts Beatriz Pérez-Cadahía, Bojan Drobic, Paula S. Espino, Shihua He, Soma Mandal, Shannon Healy, and James R. Davie
J. Biol. Chem. 2011 286: 42-49. First Published on November 10, 2010; doi:10.1074/jbc.M110.156687 [Abstract] [Full Text] [PDF] [Supplementary figures 1-4 (.pdf, 70 KB)]  

The RUN Domain of Rubicon Is Important for hVps34 Binding, Lipid Kinase Inhibition, and Autophagy Suppression Qiming Sun, Jing Zhang, Weiliang Fan, Kwun Ngok Wong, Xiaojun Ding, She Chen, and Qing Zhong
J. Biol. Chem. 2011 286: 185-191. First Published on November 9, 2010; doi:10.1074/jbc.M110.126425 [Abstract] [Full Text] [PDF] [Supplementary figures S1-S4 (.pdf, 1.2 MB)]  

Structure-Function Analysis of the Yeast Mitochondrial Rho GTPase, Gem1p: IMPLICATIONS FOR MITOCHONDRIAL INHERITANCE Takumi Koshiba, Holly A. Holman, Kenji Kubara, Kai Yasukawa, Shun-ichiro Kawabata, Koji Okamoto, Jane Macfarlane, and Janet M. Shaw
J. Biol. Chem. 2011 286: 354-362. First Published on October 29, 2010; doi:10.1074/jbc.M110.180034 [Abstract] [Full Text] [PDF]  

TDP2/TTRAP Is the Major 5'-Tyrosyl DNA Phosphodiesterase Activity in Vertebrate Cells and Is Critical for Cellular Resistance to Topoisomerase II-induced DNA Damage Zhihong Zeng, Felipe Cortés-Ledesma, Sherif F. El Khamisy, and Keith W. Caldecott
J. Biol. Chem. 2011 286: 403-409. First Published on October 28, 2010; doi:10.1074/jbc.M110.181016 [Abstract] [Full Text] [PDF] [supplementary figures 1 and 2 (.pdf, 221 KB)] AUTHOR'S CHOICE  


MicroRNA-210 Regulates Cancer Cell Proliferation through Targeting Fibroblast Growth Factor Receptor-like 1 (FGFRL1) Soken Tsuchiya, Takeshi Fujiwara, Fumiaki Sato, Yutaka Shimada, Eiji Tanaka, Yoshiharu Sakai, Kazuharu Shimizu, and Gozoh Tsujimoto
J. Biol. Chem. 2011 286: 420-428. First Published on November 2, 2010; doi:10.1074/jbc.M110.170852 [Abstract] [Full Text] [PDF] [Supplemental Data (.pdf, 180 KB)]  

SLUG-induced Elevation of D1 Cyclin in Breast Cancer Cells through the Inhibition of Its Ubiquitination Mukul K. Mittal, Kshipra Singh, Smita Misra, and Gautam Chaudhuri
J. Biol. Chem. 2011 286: 469-479. First Published on November 2, 2010; doi:10.1074/jbc.M110.164384 [Abstract] [Full Text] [PDF] [Supplemental Figs and Tables (.pdf, 473 KB)]  

BH3 Domains other than Bim and Bid Can Directly Activate Bax/Bak Han Du, Jacob Wolf, Blanca Schafer, Tudor Moldoveanu, Jerry E. Chipuk, and Tomomi Kuwana
J. Biol. Chem. 2011 286: 491-501. First Published on November 1, 2010; doi:10.1074/jbc.M110.167148 [Abstract] [Full Text] [PDF]  

Identification of a Novel Dynein Binding Domain in Nudel Essential for Spindle Pole Organization in Xenopus Egg Extract Shusheng Wang and Yixian Zheng
J. Biol. Chem. 2011 286: 587-593. First Published on November 5, 2010; doi:10.1074/jbc.M110.181578 [Abstract] [Full Text] [PDF] [Supplemental Fig.S1 (.pdf, 3.0 MB)] AUTHOR'S CHOICE  


Negative Regulation of EGFR-Vav2 Signaling Axis by Cbl Ubiquitin Ligase Controls EGF Receptor-mediated Epithelial Cell Adherens Junction Dynamics and Cell Migration Lei Duan, Srikumar M. Raja, Gengsheng Chen, Sumeet Virmani, Stetson H. Williams, Robert J. Clubb, Chandrani Mukhopadhyay, Mark A. Rainey, Guoguang Ying, Manjari Dimri, Jing Chen, Alagarsamy L. Reddi, Mayumi Naramura, Vimla Band, and Hamid Band
J. Biol. Chem. 2011 286: 620-633. First Published on October 12, 2010; doi:10.1074/jbc.M110.188086 [Abstract] [Full Text] [PDF] AUTHOR'S CHOICE  


KCNQ1 Channels Voltage Dependence through a Voltage-dependent Binding of the S4-S5 Linker to the Pore Domain Frank S. Choveau, Nicolas Rodriguez, Fayal Abderemane Ali, Alain J. Labro, Thierry Rose, Shehrazade Dahimène, Hélène Boudin, Carole Le Hénaff, Denis Escande, Dirk J. Snyders, Flavien Charpentier, Jean Mérot, Isabelle Baró, and Gildas Loussouarn
J. Biol. Chem. 2011 286: 707-716. First Published on October 12, 2010; doi:10.1074/jbc.M110.146324 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Identification and Functional Characterization of TMEM16A, a Ca2+-activated Cl– Channel Activated by Extracellular Nucleotides, in Biliary Epithelium Amal K. Dutta, Al-karim Khimji, Charles Kresge, Abhijit Bugde, Michael Dougherty, Victoria Esser, Yoshiyuki Ueno, Shannon S. Glaser, Gianfranco Alpini, Don C. Rockey, and Andrew P. Feranchak
J. Biol. Chem. 2011 286: 766-776. First Published on November 1, 2010; doi:10.1074/jbc.M110.164970 [Abstract] [Full Text] [PDF] [Supplemental Data (.pdf, 536 KB)]  

The N-terminal Fragment from Caspase-cleaved Serine/Arginine Protein-specific Kinase2 (SRPK2) Translocates into the Nucleus and Promotes Apoptosis Yi Hong, Sung-Wuk Jang, and Keqiang Ye
J. Biol. Chem. 2011 286: 777-786. First Published on November 5, 2010; doi:10.1074/jbc.M110.193441 [Abstract] [Full Text] [PDF]  

N-cadherin and Neuroligins Cooperate to Regulate Synapse Formation in Hippocampal Cultures Mytyl Aiga, Joshua N. Levinson, and Shernaz X. Bamji
J. Biol. Chem. 2011 286: 851-858. First Published on November 5, 2010; doi:10.1074/jbc.M110.176305 [Abstract] [Full Text] [PDF]  


Enzymology

 Processivity of Cellobiohydrolases Is Limited by the Substrate Mihhail Kurasin and Priit Väljamäe
J. Biol. Chem. 2011 286: 169-177. First Published on November 4, 2010; doi:10.1074/jbc.M110.161059 [Abstract] [Full Text] [PDF] [Supplemental Data (.pdf, 235 KB)]  

pH-dependent Studies Reveal an Efficient Hydroxylation Mechanism of the Oxygenase Component of p-Hydroxyphenylacetate 3-Hydroxylase Nantidaporn Ruangchan, Chanakan Tongsook, Jeerus Sucharitakul, and Pimchai Chaiyen
J. Biol. Chem. 2011 286: 223-233. First Published on October 28, 2010; doi:10.1074/jbc.M110.163881 [Abstract] [Full Text] [PDF] [Supplemental Data (.pdf, 197 KB)]  

Platelet Factor 4 Inhibits Thrombomodulin-dependent Activation of Thrombin-activatable Fibrinolysis Inhibitor (TAFI) by Thrombin Laurent O. Mosnier
J. Biol. Chem. 2011 286: 502-510. First Published on November 1, 2010; doi:10.1074/jbc.M110.147959 [Abstract] [Full Text] [PDF] [Supplemental Data (.pdf, 503 KB)]  

Kallikrein-related Peptidase-8 (KLK8) Is an Active Serine Protease in Human Epidermis and Sweat and Is Involved in a Skin Barrier Proteolytic Cascade Azza Eissa, Vanessa Amodeo, Christopher R. Smith, and Eleftherios P. Diamandis
J. Biol. Chem. 2011 286: 687-706. First Published on October 12, 2010; doi:10.1074/jbc.M110.125310 [Abstract] [Full Text] [PDF] [Supplemental Data]  


Gene Regulation

 Phosphorylation of RUNX1 by Cyclin-dependent Kinase Reduces Direct Interaction with HDAC1 and HDAC3 Hong Guo and Alan D. Friedman
J. Biol. Chem. 2011 286: 208-215. First Published on November 8, 2010; doi:10.1074/jbc.M110.149013 [Abstract] [Full Text] [PDF]  

Interaction of Escherichia coli RNA Polymerase 70 Subunit with Promoter Elements in the Context of Free 70, RNA Polymerase Holoenzyme, and the β'-70 Complex Vladimir Mekler, Olga Pavlova, and Konstantin Severinov
J. Biol. Chem. 2011 286: 270-279. First Published on October 15, 2010; doi:10.1074/jbc.M110.174102 [Abstract] [Full Text] [PDF] [Supplemental Data (.pdf, 257 KB)]  

The DNA Damage Response Pathway Regulates the Alternative Splicing of the Apoptotic Mediator Bcl-x Lulzim Shkreta, Laetitia Michelle, Johanne Toutant, Michel L. Tremblay, and Benoit Chabot
J. Biol. Chem. 2011 286: 331-340. First Published on October 27, 2010; doi:10.1074/jbc.M110.162644 [Abstract] [Full Text] [PDF] [Supplemental Data (.pdf, 391 KB)]  

Oct1 Is a Switchable, Bipotential Stabilizer of Repressed and Inducible Transcriptional States Arvind Shakya, Jinsuk Kang, Jeffrey Chumley, Matthew A. Williams, and Dean Tantin
J. Biol. Chem. 2011 286: 450-459. First Published on November 4, 2010; doi:10.1074/jbc.M110.174045 [Abstract] [Full Text] [PDF] [Supplemental figure (.pdf, 638 KB)]  

Class II Histone Deacetylases Limit GLUT4 Gene Expression during Adipocyte Differentiation Juston Weems and Ann Louise Olson
J. Biol. Chem. 2011 286: 460-468. First Published on November 3, 2010; doi:10.1074/jbc.M110.157107 [Abstract] [Full Text] [PDF]  

Characterization of Promoter Elements Regulating the Expression of the Human Neurotensin/Neuromedin N Gene Xiaofu Wang, Pat Gulhati, Jing Li, Paul R. Dobner, Heidi Weiss, Courtney M. Townsend, Jr, and B. Mark Evers
J. Biol. Chem. 2011 286: 542-554. First Published on October 28, 2010; doi:10.1074/jbc.M110.145664 [Abstract] [Full Text] [PDF]  

Prefoldin 5 Is Required for Normal Sensory and Neuronal Development in a Murine Model YongSuk Lee, Richard S. Smith, Wanda Jordan, Benjamin L. King, Jungyeon Won, Jose M. Valpuesta, Jurgen K. Naggert, and Patsy M. Nishina
J. Biol. Chem. 2011 286: 726-736. First Published on October 18, 2010; doi:10.1074/jbc.M110.177352 [Abstract] [Full Text] [PDF]  

Histidine 103 in Fra2 Is an Iron-Sulfur Cluster Ligand in the [2Fe-2S] Fra2-Grx3 Complex and Is Required for in Vivo Iron Signaling in Yeast Haoran Li, Daphne T. Mapolelo, Nin N. Dingra, Greg Keller, Pamela J. Riggs-Gelasco, Dennis R. Winge, Michael K. Johnson, and Caryn E. Outten
J. Biol. Chem. 2011 286: 867-876. First Published on October 26, 2010; doi:10.1074/jbc.M110.184176 [Abstract] [Full Text] [PDF] [Supplemental Data (.pdf, 259 KB)]  


Genomics and Proteomics

 Revisiting Iodination Sites in Thyroglobulin with an Organ-oriented Shotgun Strategy Alain Dedieu, Jean-Charles Gaillard, Thierry Pourcher, Elisabeth Darrouzet, and Jean Armengaud
J. Biol. Chem. 2011 286: 259-269. First Published on October 26, 2010; doi:10.1074/jbc.M110.159483 [Abstract] [Full Text] [PDF] [Table S5
(.xls, 555 KB)]  

The Essential Role of Clathrin-mediated Endocytosis in the Infectious Entry of Human Enterovirus 71 Khairunnisa' Mohamed Hussain, Kim Lian Janet Leong, Mary Mah-Lee Ng, and Justin Jang Hann Chu
J. Biol. Chem. 2011 286: 309-321. First Published on October 18, 2010; doi:10.1074/jbc.M110.168468 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Functional Gene Expression Profiling in Yeast Implicates Translational Dysfunction in Mutant Huntingtin Toxicity Eran Tauber, Leonor Miller-Fleming, Robert P. Mason, Wanda Kwan, Jannine Clapp, Nicola J. Butler, Tiago F. Outeiro, Paul J. Muchowski, and Flaviano Giorgini
J. Biol. Chem. 2011 286: 410-419. First Published on November 2, 2010; doi:10.1074/jbc.M110.101527 [Abstract] [Full Text] [PDF] [Supplemental Data (.pdf, 897 KB)]  

Proteomic Analysis of Native Hepatocyte Nuclear Factor-4 (HNF4) Isoforms, Phosphorylation Status, and Interactive Cofactors Kenji Daigo, Takeshi Kawamura, Yoshihiro Ohta, Riuko Ohashi, Satoshi Katayose, Toshiya Tanaka, Hiroyuki Aburatani, Makoto Naito, Tatsuhiko Kodama, Sigeo Ihara, and Takao Hamakubo
J. Biol. Chem. 2011 286: 674-686. First Published on November 3, 2010; doi:10.1074/jbc.M110.154732 [Abstract] [Full Text] [PDF] [supplemental Table S1 (.doc, 54 KB)] AUTHOR'S CHOICE  


Integrated Quantitative Analysis of the Phosphoproteome and Transcriptome in Tamoxifen-resistant Breast Cancer Masaaki Oyama, Takeshi Nagashima, Takashi Suzuki, Hiroko Kozuka-Hata, Noriko Yumoto, Yuichi Shiraishi, Kazuhiro Ikeda, Yoko Kuroki, Noriko Gotoh, Takanori Ishida, Satoshi Inoue, Hiroaki Kitano, and Mariko Okada-Hatakeyama
J. Biol. Chem. 2011 286: 818-829. First Published on November 2, 2010; doi:10.1074/jbc.M110.156877 


Glycobiology and Extracellular Matrices

 Heparan Sulfate Regulates VEGF165- and VEGF121-mediated Vascular Hyperpermeability Ding Xu, Mark M. Fuster, Roger Lawrence, and Jeffrey D. Esko
J. Biol. Chem. 2011 286: 737-745. First Published on October 25, 2010; doi:10.1074/jbc.M110.177006
Immunology

 Bryostatin-1, a Naturally Occurring Antineoplastic Agent, Acts as a Toll-like Receptor 4 (TLR-4) Ligand and Induces Unique Cytokines and Chemokines in Dendritic Cells Maria Eugenia Ariza, Rupal Ramakrishnan, Narendra P. Singh, Ashok Chauhan, Prakash S. Nagarkatti, and Mitzi Nagarkatti
J. Biol. Chem. 2011 286: 24-34. First Published on October 29, 2010; doi:10.1074/jbc.M110.135921 [Abstract] [Full Text] [PDF]  

Sodium Overload and Water Influx Activate the NALP3 Inflammasome Christine Schorn, Benjamin Frey, Kirsten Lauber, Christina Janko, Moritz Strysio, Hildegard Keppeler, Udo S. Gaipl, Reinhard E. Voll, Eva Springer, Luis E. Munoz, Georg Schett, and Martin Herrmann
J. Biol. Chem. 2011 286: 35-41. First Published on November 4, 2010; doi:10.1074/jbc.M110.139048 [Abstract] [Full Text] [PDF] [Supplemental Data (.pdf, 19 KB)]  

Variable Antibody-dependent Activation of Complement by Functionalized Phospholipid Nanoparticle Surfaces Christine T. N. Pham, Lynne M. Mitchell, Jennifer L. Huang, Christopher M. Lubniewski, Otto F. Schall, J. Kendall Killgore, Dipanjan Pan, Samuel A. Wickline, Gregory M. Lanza, and Dennis E. Hourcade
J. Biol. Chem. 2011 286: 123-130. First Published on November 3, 2010; doi:10.1074/jbc.M110.180760 [Abstract] [Full Text] [PDF]  

Interleukin-2-inducible T Cell Kinase (Itk) Network Edge Dependence for the Maturation of iNKT Cell Qian Qi, Mingcan Xia, Yuting Bai, Sanhong Yu, Margherita Cantorna, and Avery August
J. Biol. Chem. 2011 286: 138-146. First Published on October 29, 2010; doi:10.1074/jbc.M110.148205 [Abstract] [Full Text] [PDF]  


Membrane Biology

 Surprising Substrate Versatility in SLC5A6: Na+-COUPLED I– TRANSPORT BY THE HUMAN Na+/MULTIVITAMIN TRANSPORTER (hSMVT) Fernanda Delmondes de Carvalho and Matthias Quick
J. Biol. Chem. 2011 286: 131-137. First Published on October 27, 2010; doi:10.1074/jbc.M110.167197 [Abstract] [Full Text] [PDF]  

Analysis of Three-dimensional Systems for Developing and Mature Kidneys Clarifies the Role of OAT1 and OAT3 in Antiviral Handling Megha A. Nagle, David M. Truong, Ankur V. Dnyanmote, Sun-Young Ahn, Satish A. Eraly, Wei Wu, and Sanjay K. Nigam
J. Biol. Chem. 2011 286: 243-251. First Published on October 4, 2010; doi:10.1074/jbc.M110.139949 [Abstract] [Full Text] [PDF]  

Pancreatic Bicarbonate Secretion Involves Two Proton Pumps Ivana Novak, Jing Wang, Katrine L. Henriksen, Kristian A. Haanes, Simon Krabbe, Roland Nitschke, and Susanne E. Hede
J. Biol. Chem. 2011 286: 280-289. First Published on October 26, 2010; doi:10.1074/jbc.M110.136382 [Abstract] [Full Text] [PDF] [Supplemental Data (.pdf, 103 KB)]  

Acetylcholine Receptor Organization in Membrane Domains in Muscle Cells: EVIDENCE FOR RAPSYN-INDEPENDENT AND RAPSYN-DEPENDENT MECHANISMS Joachim Piguet, Christoph Schreiter, Jean-Manuel Segura, Horst Vogel, and Ruud Hovius
J. Biol. Chem. 2011 286: 363-369. First Published on October 26, 2010; doi:10.1074/jbc.M110.139782 [Abstract] [Full Text] [PDF]  

Constraint-based, Homology Model of the Extracellular Domain of the Epithelial Na+ Channel  Subunit Reveals a Mechanism of Channel Activation by Proteases Ossama B. Kashlan, Joshua L. Adelman, Sora Okumura, Brandon M. Blobner, Zachary Zuzek, Rebecca P. Hughey, Thomas R. Kleyman, and Michael Grabe
J. Biol. Chem. 2011 286: 649-660. First Published on October 25, 2010; doi:10.1074/jbc.M110.167098 [Abstract] [Full Text] [PDF] [Supplemental Data (.pdf, 543 KB)]  


Metabolism

Liver X Receptor (LXR) Regulates Human Adipocyte Lipolysis Britta M. Stenson, Mikael Rydén, Nicolas Venteclef, Ingrid Dahlman, Annie M. L. Pettersson, Aline Mairal, Gaby Åström, Lennart Blomqvist, Victoria Wang, Johan W. E. Jocken, Karine Clément, Dominique Langin, Peter Arner, and Jurga Laurencikiene
J. Biol. Chem. 2011 286: 370-379. First Published on October 28, 2010; doi:10.1074/jbc.M110.179499 [Abstract] [Full Text] [PDF] [Supplemental Data (.pdf, 21 KB)]  

Heart-type Fatty Acid-binding Protein Is Essential for Efficient Brown Adipose Tissue Fatty Acid Oxidation and Cold Tolerance Laurent Vergnes, Robert Chin, Stephen G. Young, and Karen Reue
J. Biol. Chem. 2011 286: 380-390. First Published on November 1, 2010; doi:10.1074/jbc.M110.184754 [Abstract] [Full Text] [PDF]  


Microbiology

 The Oligopeptidase B of Leishmania Regulates Parasite Enolase and Immune Evasion Ryan K. Swenerton, Shuyi Zhang, Mohammed Sajid, Katalin F. Medzihradszky, Charles S. Craik, Ben L. Kelly, and James H. McKerrow
J. Biol. Chem. 2011 286: 429-440. First Published on October 20, 2010; doi:10.1074/jbc.M110.138313 [Abstract] [Full Text] [PDF] [Supplemental Data (.pdf, 79 KB)]  

Mechanisms of Autoinhibition of IRF-7 and a Probable Model for Inactivation of IRF-7 by Kaposi's Sarcoma-associated Herpesvirus Protein ORF45 Narayanan Sathish, Fan Xiu Zhu, Ellis E. Golub, Qiming Liang, and Yan Yuan
J. Biol. Chem. 2011 286: 746-756. First Published on October 27, 2010; doi:10.1074/jbc.M110.150920 [Abstract] [Full Text] [PDF] [Supplemental Data (.pdf, 4.0 MB)]  


Molecular Bases of Disease

 IL-6-induced Enhancement of c-Myc Translation in Multiple Myeloma Cells: CRITICAL ROLE OF CYTOPLASMIC LOCALIZATION OF THE RNA-BINDING PROTEIN hnRNP A1 Yijiang Shi, Patrick Frost, Bao Hoang, Angelica Benavides, Joseph Gera, and Alan Lichtenstein
J. Biol. Chem. 2011 286: 67-78. First Published on October 25, 2010; doi:10.1074/jbc.M110.153221 [Abstract] [Full Text] [PDF] [supplemental figure 1 (.pdf, 22 KB)]  

Basal Bioenergetic Abnormalities in Skeletal Muscle from Ryanodine Receptor Malignant Hyperthermia-susceptible R163C Knock-in Mice Cecilia Giulivi, Catherine Ross-Inta, Alicja Omanska-Klusek, Eleonora Napoli, Danielle Sakaguchi, Genaro Barrientos, Paul D. Allen, and Isaac N. Pessah
J. Biol. Chem. 2011 286: 99-113. First Published on October 26, 2010; doi:10.1074/jbc.M110.153247 [Abstract] [Full Text] [PDF] [Supplemental Data (.pdf, 84 KB)]  

Cancer-associated p53 Tetramerization Domain Mutants: QUANTITATIVE ANALYSIS REVEALS A LOW THRESHOLD FOR TUMOR SUPPRESSOR INACTIVATION Rui Kamada, Takao Nomura, Carl W. Anderson, and Kazuyasu Sakaguchi
J. Biol. Chem. 2011 286: 252-258. First Published on October 26, 2010; doi:10.1074/jbc.M110.174698 [Abstract] [Full Text] [PDF] [Supplemental Data (.pdf, 13.1 MB)]  

Cyclooxygenase-2 Deficiency Attenuates Adipose Tissue Differentiation and Inflammation in Mice Sarbani Ghoshal, Darshini B. Trivedi, Gregory A. Graf, and Charles D. Loftin
J. Biol. Chem. 2011 286: 889-898. First Published on October 20, 2010; doi:10.1074/jbc.M110.139139 [Abstract] [Full Text] [PDF]  


Molecular Biophysics

 Recognition and Specificity Determinants of the Human Cbx Chromodomains Lilia Kaustov, Hui Ouyang, Maria Amaya, Alexander Lemak, Nataliya Nady, Shili Duan, Gregory A. Wasney, Zhihong Li, Masoud Vedadi, Matthieu Schapira, Jinrong Min, and Cheryl H. Arrowsmith
J. Biol. Chem. 2011 286: 521-529. First Published on November 3, 2010; doi:10.1074/jbc.M110.191411 [Abstract] [Full Text] [PDF] [Supplemental Figure 5 (.pdf, 143 KB)] AUTHOR'S CHOICE  


The S4-S5 Linker of KCNQ1 Channels Forms a Structural Scaffold with the S6 Segment Controlling Gate Closure Alain J. Labro, Inge R. Boulet, Frank S. Choveau, Evy Mayeur, Tine Bruyns, Gildas Loussouarn, Adam L. Raes, and Dirk J. Snyders
J. Biol. Chem. 2011 286: 717-725. First Published on November 8, 2010; doi:10.1074/jbc.M110.146977 [Abstract] [Full Text] [PDF] [Supplemental Data (.pdf, 482 KB)]  

Crystallographic Complexes of Surfactant Protein A and Carbohydrates Reveal Ligand-induced Conformational Change Feifei Shang, Michael J. Rynkiewicz, Francis X. McCormack, Huixing Wu, Tanya M. Cafarella, James F. Head, and Barbara A. Seaton
J. Biol. Chem. 2011 286: 757-765. First Published on November 3, 2010; doi:10.1074/jbc.M110.175265 [Abstract] [Full Text] [PDF]  

Genetic Screen for Potassium Leaky Small Mechanosensitive Channels (MscS) in Escherichia coli: RECOGNITION OF CYTOPLASMIC β DOMAIN AS A NEW GATING ELEMENT Piotr Koprowski, Wojciech Grajkowski, Ehud Y. Isacoff, and Andrzej Kubalski
J. Biol. Chem. 2011 286: 877-888. First Published on October 26, 2010; doi:10.1074/jbc.M110.176131 [Abstract] [Full Text] [PDF] [Supplemental Data (.xlsx, 88 KB)]  


Neurobiology

 Rac GTPase-activating Protein (Rac GAP) 1-Chimaerin Undergoes Proteasomal Degradation and Is Stabilized by Diacylglycerol Signaling in Neurons Jamie R. K. Marland, DingXin Pan, and Philip C. Buttery
J. Biol. Chem. 2011 286: 199-207. First Published on November 5, 2010; doi:10.1074/jbc.M110.166728 [Abstract] [Full Text] [PDF]  

Function of Partially Duplicated Human 7 Nicotinic Receptor Subunit CHRFAM7A Gene: POTENTIAL IMPLICATIONS FOR THE CHOLINERGIC ANTI-INFLAMMATORY RESPONSE Ana M. de Lucas-Cerrillo, M. Constanza Maldifassi, Francisco Arnalich, Jaime Renart, Gema Atienza, Rocío Serantes, Jesús Cruces, Aurora Sánchez-Pacheco, Eva Andrés-Mateos, and Carmen Montiel
J. Biol. Chem. 2011 286: 594-606. First Published on November 3, 2010; doi:10.1074/jbc.M110.180067 [Abstract] [Full Text] [PDF]  

Inhibition of Myelin Membrane Sheath Formation by Oligodendrocyte-derived Exosome-like Vesicles Mostafa Bakhti, Christine Winter, and Mikael Simons
J. Biol. Chem. 2011 286: 787-796. First Published on October 26, 2010; doi:10.1074/jbc.M110.190009 [Abstract] [Full Text] [PDF] [Supplemental Data (.pdf, 426 KB)]  

Duplicated Gephyrin Genes Showing Distinct Tissue Distribution and Alternative Splicing Patterns Mediate Molybdenum Cofactor Biosynthesis, Glycine Receptor Clustering, and Escape Behavior in Zebrafish Kazutoyo Ogino, Sarah L. Ramsden, Natalie Keib, Günter Schwarz, Robert J. Harvey, and Hiromi Hirata
J. Biol. Chem. 2011 286: 806-817. First Published on September 14, 2010; doi:10.1074/jbc.M110.125500 [Abstract] [Full Text] [PDF] [Supplemental Data]  


Plant Biology

 FdC1, a Novel Ferredoxin Protein Capable of Alternative Electron Partitioning, Increases in Conditions of Acceptor Limitation at Photosystem I Ingo Voss, Tatjana Goss, Emiko Murozuka, Bianca Altmann, Kirsty J. McLean, Stephen E. J. Rigby, Andrew W. Munro, Renate Scheibe, Toshiharu Hase, and Guy T. Hanke
J. Biol. Chem. 2011 286: 50-59. First Published on October 21, 2010; doi:10.1074/jbc.M110.161562 [Abstract] [Full Text] [PDF] [Supplemental Data (.doc, 36 KB)]  

Inhibition of Arabidopsis O-Acetylserine(thiol)lyase A1 by Tyrosine Nitration Consolación Álvarez, Jorge Lozano-Juste, Luís C. Romero, Irene García, Cecilia Gotor, and José León
J. Biol. Chem. 2011 286: 578-586. First Published on November 3, 2010; doi:10.1074/jbc.M110.147678 [Abstract] [Full Text] [PDF]  


Protein Structure and Folding

 A Two-step Mechanism for the Folding of Actin by the Yeast Cytosolic Chaperonin Sarah F. Stuart, Robin J. Leatherbarrow, and Keith R. Willison
J. Biol. Chem. 2011 286: 178-184. First Published on November 5, 2010; doi:10.1074/jbc.M110.166256 [Abstract] [Full Text] [PDF]  

Molecular Rearrangements Involved in the Capsid Shell Maturation of Bacteriophage T7 Alina Ionel, Javier A. Velázquez-Muriel, Daniel Luque, Ana Cuervo, José R. Castón, José M. Valpuesta, Jaime Martín-Benito, and José L. Carrascosa
J. Biol. Chem. 2011 286: 234-242. First Published on October 20, 2010; doi:10.1074/jbc.M110.187211 [Abstract] [Full Text] [PDF] [Author profile][Supplemental Data (.pdf, 949 KB)] [Summary]  

X-ray and Biochemical Analysis of N370S Mutant Human Acid β-Glucosidase Ronnie R. Wei, Heather Hughes, Susan Boucher, Julie J. Bird, Nicholas Guziewicz, Scott M. Van Patten, Huawei Qiu, Clark Qun Pan, and Tim Edmunds
J. Biol. Chem. 2011 286: 299-308. First Published on October 27, 2010; doi:10.1074/jbc.M110.150433 [Abstract] [Full Text] [PDF] [Supplemental Data (.pdf, 325 KB)]  

Structural Basis for c-KIT Inhibition by the Suppressor of Cytokine Signaling 6 (SOCS6) Ubiquitin Ligase Fahad Zadjali, Ashley C. W. Pike, Mattias Vesterlund, Jianmin Sun, Chenggang Wu, Shawn S. C. Li, Lars Rönnstrand, Stefan Knapp, Alex N. Bullock, and Amilcar Flores-Morales
J. Biol. Chem. 2011 286: 480-490. First Published on October 28, 2010; doi:10.1074/jbc.M110.173526 [Abstract] [Full Text] [PDF]  

Structural Modeling and Electron Paramagnetic Resonance Spectroscopy of the Human Na+/H+ Exchanger Isoform 1, NHE1 Eva B. Nygaard, Jens O. Lagerstedt, Gabriel Bjerre, Biao Shi, Madhu Budamagunta, Kristian A. Poulsen, Stine Meinild, Robert R. Rigor, John C. Voss, Peter M. Cala, and Stine F. Pedersen
J. Biol. Chem. 2011 286: 634-648. First Published on October 25, 2010; doi:10.1074/jbc.M110.159202 [Abstract] [Full Text] [PDF] [Supplementary figure legends
(.pdf, 9 KB)]  

Structural and Biological Properties of the Drosophila Insulin-like Peptide 5 Show Evolutionary Conservation Waseem Sajid, Nikolaj Kulahin, Gerd Schluckebier, Ulla Ribel, Hope Rosalind Henderson, Marc Tatar, Bo Falck Hansen, Angela Manegold Svendsen, Vladislav V. Kiselyov, Per Nørgaard, Per-Olof Wahlund, Jakob Brandt, Ronald A. Kohanski, Asser Sloth Andersen, and Pierre De Meyts
J. Biol. Chem. 2011 286: 661-673. First Published on October 25, 2010; doi:10.1074/jbc.M110.156018 [Abstract] [Full Text] [PDF] [Supplemental information (.pdf, 1.4 MB)]  

Homophilic Adhesion Mechanism of Neurofascin, a Member of the L1 Family of Neural Cell Adhesion Molecules Heli Liu, Pamela J. Focia, and Xiaolin He
J. Biol. Chem. 2011 286: 797-805. First Published on November 3, 2010; doi:10.1074/jbc.M110.180281 [Abstract] [Full Text] [PDF] [Supplemental Figures Combined (.pdf, 4.0 MB)]  

Response of Rigor Cross-bridges to Stretch Detected by Fluorescence Lifetime Imaging Microscopy of Myosin Essential Light Chain in Skeletal Muscle Fibers Dmitry S. Ushakov, Valentina Caorsi, Delisa Ibanez-Garcia, Hugh B. Manning, Antonios D. Konitsiotis, Timothy G. West, Christopher Dunsby, Paul M. French, and Michael A. Ferenczi
J. Biol. Chem. 2011 286: 842-850. First Published on November 5, 2010; doi:10.1074/jbc.M110.149526 [Abstract] [Full Text] [PDF] [Supplemental figures (.pdf, 127 KB)]  


Protein Synthesis and Degradation

 Biochemical and Structural Studies of a HECT-like Ubiquitin Ligase from Escherichia coli O157:H7 David Yin-wei Lin, Jianbo Diao, Daoguo Zhou, and Jue Chen
J. Biol. Chem. 2011 286: 441-449. First Published on October 27, 2010; doi:10.1074/jbc.M110.167643 [Abstract] [Full Text] [PDF] AUTHOR'S CHOICE  


Docking-dependent Ubiquitination of the Interferon Regulatory Factor-1 Tumor Suppressor Protein by the Ubiquitin Ligase CHIP Vikram Narayan, Emmanuelle Pion, Vivien Landré, Petr Müller, and Kathryn L. Ball
J. Biol. Chem. 2011 286: 607-619. First Published on October 14, 2010; doi:10.1074/jbc.M110.153122 [Abstract] [Full Text] [PDF] [Supplemental Data (.pdf, 162 KB)]  


RNA

 Rho-dependent Termination of ssrS (6S RNA) Transcription in Escherichia coli: IMPLICATION FOR 3' PROCESSING OF 6S RNA AND EXPRESSION OF DOWNSTREAM ygfA (PUTATIVE 5-FORMYL-TETRAHYDROFOLATE CYCLO-LIGASE) Huiseok Chae, Kook Han, Kwang-sun Kim, Hongmarn Park, Jungmin Lee, and Younghoon Lee
J. Biol. Chem. 2011 286: 114-122. First Published on October 29, 2010; doi:10.1074/jbc.M110.150201 [Abstract] [Full Text] [PDF]  

The RNA Binding Motif Protein 15B (RBM15B/OTT3) Is a Functional Competitor of Serine-Arginine (SR) Proteins and Antagonizes the Positive Effect of the CDK11p110-Cyclin L2 Complex on Splicing Pascal Loyer, Adeline Busson, Janeen H. Trembley, Judith Hyle, Jose Grenet, Wei Zhao, Catherine Ribault, Tristan Montier, Vincent J. Kidd, and Jill M. Lahti
J. Biol. Chem. 2011 286: 147-159. First Published on November 2, 2010; doi:10.1074/jbc.M110.192518 [Abstract] [Full Text] [PDF] [Supplemental Data (.pdf, 2.1 MB)]  

Engineered External Guide Sequences Effectively Block Viral Gene Expression and Replication in Cultured Cells Xiaohong Jiang, Yong Bai, Paul Rider, Kihoon Kim, Chen-Yu Zhang, Sangwei Lu, and Fenyong Liu
J. Biol. Chem. 2011 286: 322-330. First Published on October 27, 2010; doi:10.1074/jbc.M110.158857 [Abstract] [Full Text] [PDF]  


Signal Transduction

 Metformin Activates AMP Kinase through Inhibition of AMP Deaminase Jiangyong Ouyang, Rahulkumar A. Parakhia, and Raymond S. Ochs
J. Biol. Chem. 2011 286: 1-11. First Published on November 8, 2010; doi:10.1074/jbc.M110.121806 [Abstract] [Full Text] [PDF]  

Exogenous Recombinant Dimeric Neuropilin-1 Is Sufficient to Drive Angiogenesis Katarzyna A. Uniewicz, Michael J. Cross, and David G. Fernig
J. Biol. Chem. 2011 286: 12-23. First Published on October 18, 2010; doi:10.1074/jbc.M110.190801 [Abstract] [Full Text] [PDF] [Supplemental Data (.pdf, 660 KB)]  

Up-regulation of Adiponectin by Resveratrol: THE ESSENTIAL ROLES OF THE Akt/FOXO1 AND AMP-ACTIVATED PROTEIN KINASE SIGNALING PATHWAYS AND DsbA-L Anping Wang, Meilian Liu, Xianling Liu, Lily Q. Dong, Randolph D. Glickman, Thomas J. Slaga, Zhiguang Zhou, and Feng Liu
J. Biol. Chem. 2011 286: 60-66. First Published on October 27, 2010; doi:10.1074/jbc.M110.188144 [Abstract] [Full Text] [PDF]  

ErbB2 Stabilizes Epidermal Growth Factor Receptor (EGFR) Expression via Erk and Sprouty2 in Extracellular Matrix-detached Cells Alexandra R. Grassian, Zachary T. Schafer, and Joan S. Brugge
J. Biol. Chem. 2011 286: 79-90. First Published on October 18, 2010; doi:10.1074/jbc.M110.169821 [Abstract] [Full Text] [PDF] [Author profile] [Summary]  

Interaction of Two Phagocytic Host Defense Systems: Fc RECEPTORS AND COMPLEMENT RECEPTOR 3 Zhen-Yu Huang, Sharon Hunter, Paul Chien, Moo-Kyung Kim, Tae-Hee Han-Kim, Zena K. Indik, and Alan D. Schreiber
J. Biol. Chem. 2011 286: 160-168. First Published on November 2, 2010; doi:10.1074/jbc.M110.163030 [Abstract] [Full Text] [PDF]  

Genetic Inactivation of Kcnj16 Identifies Kir5.1 as an Important Determinant of Neuronal PCO2/pH Sensitivity M. Cristina D'Adamo, Lijun Shang, Paola Imbrici, Steve D. M. Brown, Mauro Pessia, and Stephen J. Tucker
J. Biol. Chem. 2011 286: 192-198. First Published on November 3, 2010; doi:10.1074/jbc.M110.189290 [Abstract] [Full Text] [PDF]  

c-Abl Phosphorylation of Mdm2 Facilitates Mdm2-Mdmx Complex Formation David L. Waning, Jason A. Lehman, Christopher N. Batuello, and Lindsey D. Mayo
J. Biol. Chem. 2011 286: 216-222. First Published on November 16, 2010; doi:10.1074/jbc.M110.183012 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Pannexin 1 Constitutes the Large Conductance Cation Channel of Cardiac Myocytes Marie-Cecile Kienitz, Kirsten Bender, Rolf Dermietzel, Lutz Pott, and Georg Zoidl
J. Biol. Chem. 2011 286: 290-298. First Published on November 1, 2010; doi:10.1074/jbc.M110.163477 [Abstract] [Full Text] [PDF] [Supplemental Summary File 1 (.pdf, 73 KB)]  

Negative Regulation of TGFβ Signaling by the Kinase LKB1 and the Scaffolding Protein LIP1 Anita Morén, Erna Raja, Carl-Henrik Heldin, and Aristidis Moustakas
J. Biol. Chem. 2011 286: 341-353. First Published on October 25, 2010; doi:10.1074/jbc.M110.190660 [Abstract] [Full Text] [PDF] [Supplemental Data (.pdf, 945 KB)] AUTHOR'S CHOICE  


Prostaglandin E2 Activates and Utilizes mTORC2 as a Central Signaling Locus for the Regulation of Mast Cell Chemotaxis and Mediator Release Hye Sun Kuehn, Mi-Yeon Jung, Michael A. Beaven, Dean D. Metcalfe, and Alasdair M. Gilfillan
J. Biol. Chem. 2011 286: 391-402. First Published on October 27, 2010; doi:10.1074/jbc.M110.164772 [Abstract] [Full Text] [PDF]  

Protein Kinase D1 Mediates Stimulation of DNA Synthesis and Proliferation in Intestinal Epithelial IEC-18 Cells and in Mouse Intestinal Crypts James Sinnett-Smith, Nora Rozengurt, Robert Kui, Carlos Huang, and Enrique Rozengurt
J. Biol. Chem. 2011 286: 511-520. First Published on November 4, 2010; doi:10.1074/jbc.M110.167528 [Abstract] [Full Text] [PDF] [Supplemental figures S1 to S5 (.pdf, 547 KB)]  

Cardiac Troponin T, a Sarcomeric AKAP, Tethers Protein Kinase A at the Myofilaments C. Amelia Sumandea, Mary L. Garcia-Cazarin, Catherine H. Bozio, Gail A. Sievert, C. William Balke, and Marius P. Sumandea
J. Biol. Chem. 2011 286: 530-541. First Published on November 5, 2010; doi:10.1074/jbc.M110.148684 [Abstract] [Full Text] [PDF]  

ERK1/2 Phosphorylate Raptor to Promote Ras-dependent Activation of mTOR Complex 1 (mTORC1) Audrey Carriere, Yves Romeo, Hugo A. Acosta-Jaquez, Julie Moreau, Eric Bonneil, Pierre Thibault, Diane C. Fingar, and Philippe P. Roux
J. Biol. Chem. 2011 286: 567-577. First Published on November 11, 2010; doi:10.1074/jbc.M110.159046 [Abstract] [Full Text] [PDF]  

Combined Phosphoinositide and Ca2+ Signals Mediating Receptor Specificity toward Neuronal Ca2+ Channels Oleg Zaika, Jie Zhang, and Mark S. Shapiro
J. Biol. Chem. 2011 286: 830-841. First Published on November 4, 2010; doi:10.1074/jbc.M110.166033 [Abstract] [Full Text] [PDF]  

Radixin Assembles cAMP Effectors Epac and PKA into a Functional cAMP Compartment: ROLE IN cAMP-DEPENDENT CELL PROLIFERATION Daniel Hochbaum, Guillermo Barila, Fernando Ribeiro-Neto, and Daniel L. Altschuler
J. Biol. Chem. 2011 286: 859-866. First Published on November 3, 2010; doi:10.1074/jbc.M110.163816 [Abstract] [Full Text] [PDF]  

  
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