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:: J. Biol. Chem. Table of Contents for 14 January 2011 ::

 AWT IMAGE

 

 Journal of Biological Chemistry Table of Contents Alert

   
A new issue of Journal of Biological Chemistry is available online: 14 January 2011; Vol. 286, No. 2

The below Table of Contents is available online at:

http://www.jbc.org/content/vol286/issue2/index.dtl?etoc



Papers of the Week

 Making Light of cAMP Signaling: Light Modulation of Cellular cAMP by a Small Bacterial Photoactivated Adenylyl Cyclase, bPAC, of the Soil Bacterium Beggiatoa
J. Biol. Chem. 2011 286: e99903. First Published ; doi:10.1074/jbc.P110.185496

A Comprehensive and Complex Library: Identification of Neuronal RNA Targets of TDP-43-containing Ribonucleoprotein Complexes
J. Biol. Chem. 2011 286: e99904. First Published ; doi:10.1074/jbc.P110.190884   


Bioenergetics

 Cardiac and Skeletal Muscle Defects in a Mouse Model of Human Barth Syndrome Devrim Acehan, Frederic Vaz, Riekelt H. Houtkooper, Jeanne James, Vicky Moore, Chonan Tokunaga, Willem Kulik, Janaka Wansapura, Matthew J. Toth, Arnold Strauss, and Zaza Khuchua
J. Biol. Chem. 2011 286: 899-908. First Published on November 9, 2010; doi:10.1074/jbc.M110.171439 

  

Regulation of the Inner Membrane Mitochondrial Permeability Transition by the Outer Membrane Translocator Protein (Peripheral Benzodiazepine Receptor) Justina Sileikyte, Valeria Petronilli, Alessandra Zulian, Federica Dabbeni-Sala, Giuseppe Tognon, Peter Nikolov, Paolo Bernardi, and Fernanda Ricchelli
J. Biol. Chem. 2011 286: 1046-1053. First Published on November 9, 2010; doi:10.1074/jbc.M110.172486 [Abstract] [Full Text] [PDF]  


Cell Biology

Vascular Endothelial Growth Factor A (VEGF-A) Induces Endothelial and Cancer Cell Migration through Direct Binding to Integrin 9β1: IDENTIFICATION OF A SPECIFIC 9β1 BINDING SITE Saji Oommen, Shiv K. Gupta, and Nicholas E. Vlahakis
J. Biol. Chem. 2011 286: 1083-1092. First Published on November 11, 2010; doi:10.1074/jbc.M110.175158

Dematin, a Component of the Erythrocyte Membrane Skeleton, Is Internalized by the Malaria Parasite and Associates with Plasmodium 14-3-3 Marco Lalle, Chiara Currà, Fabio Ciccarone, Tomasino Pace, Serena Cecchetti, Luca Fantozzi, Bernhard Ay, Catherine Braun Breton, and Marta Ponzi
J. Biol. Chem. 2011 286: 1227-1236. First Published on November 17, 2010; doi:10.1074/jbc.M110.194613 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Regulator of G Protein Signaling 6 (RGS6) Induces Apoptosis via a Mitochondrial-dependent Pathway Not Involving Its GTPase-activating Protein Activity Biswanath Maity, Jianqi Yang, Jie Huang, Ryan W. Askeland, Soumen Bera, and Rory A. Fisher
J. Biol. Chem. 2011 286: 1409-1419. First Published on November 1, 2010; doi:10.1074/jbc.M110.186700 [Abstract] [Full Text] [PDF]  

Bifunctional Apoptosis Regulator (BAR), an Endoplasmic Reticulum (ER)-associated E3 Ubiquitin Ligase, Modulates BI-1 Protein Stability and Function in ER Stress Juan Rong, Lili Chen, Julia I. Toth, Marianna Tcherpakov, Matthew D. Petroski, and John C. Reed
J. Biol. Chem. 2011 286: 1453-1463. First Published on November 10, 2010; doi:10.1074/jbc.M110.175232 [Abstract] [Full Text] [PDF] [Supplemental Figures 1-14 (.pdf, 999 KB)]  

Desmosome Assembly and Cell-Cell Adhesion Are Membrane Raft-dependent Processes Natasa Resnik, Kristina Sepcic, Ana Plemenitas, Reinhard Windoffer, Rudolf Leube, and Peter Veranic
J. Biol. Chem. 2011 286: 1499-1507. First Published on November 11, 2010; doi:10.1074/jbc.M110.189464 [Abstract] [Full Text] [PDF]  

ZFP260 Is an Inducer of Cardiac Hypertrophy and a Nuclear Mediator of Endothelin-1 Signaling Hiba Komati, Wael Maharsy, Janie Beauregard, Salim Hayek, and Mona Nemer
J. Biol. Chem. 2011 286: 1508-1516. First Published on November 4, 2010; doi:10.1074/jbc.M110.162966 [Abstract] [Full Text] [PDF]  

Dopamine D3 Receptors Are Down-regulated following Heterologous Endocytosis by a Specific Interaction with G Protein-coupled Receptor-associated Sorting Protein-1 Dawn Thompson and Jennifer L. Whistler
J. Biol. Chem. 2011 286: 1598-1608. First Published on October 28, 2010; doi:10.1074/jbc.M110.158345 [Abstract] [Full Text] [PDF] [Supplemental Figure 1 (.pdf, 2.1 MB)]  

CENP-U Cooperates with Hec1 to Orchestrate Kinetochore-Microtubule Attachment Shasha Hua, Zhikai Wang, Kai Jiang, Yuejia Huang, Tarsha Ward, Lingli Zhao, Zhen Dou, and Xuebiao Yao
J. Biol. Chem. 2011 286: 1627-1638. First Published on November 5, 2010; doi:10.1074/jbc.M110.174946 [Abstract] [Full Text] [PDF] [Supplemental Data (.pdf, 1.6 MB)]  


Enzymology

Autoxidative and Cyclooxygenase-2 Catalyzed Transformation of the Dietary Chemopreventive Agent Curcumin Markus Griesser, Valentina Pistis, Takashi Suzuki, Noemi Tejera, Derek A. Pratt, and Claus Schneider
J. Biol. Chem. 2011 286: 1114-1124. First Published on November 11, 2010; doi:10.1074/jbc.M110.178806 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Light Modulation of Cellular cAMP by a Small Bacterial Photoactivated Adenylyl Cyclase, bPAC, of the Soil Bacterium Beggiatoa Manuela Stierl, Patrick Stumpf, Daniel Udwari, Ronnie Gueta, Rolf Hagedorn, Aba Losi, Wolfgang Gärtner, Linda Petereit, Marina Efetova, Martin Schwarzel, Thomas G. Oertner, Georg Nagel, and Peter Hegemann
J. Biol. Chem. 2011 286: 1181-1188. First Published on October 28, 2010; doi:10.1074/jbc.M110.185496 [Abstract] [Full Text] [PDF] [Author profile] [Summary]  

Spectroscopic Studies on the [4Fe-4S] Cluster in Adenosine 5'-Phosphosulfate Reductase from Mycobacterium tuberculosis Devayani P. Bhave, Jiyoung A. Hong, Michael Lee, Wei Jiang, Carsten Krebs, and Kate S. Carroll
J. Biol. Chem. 2011 286: 1216-1226. First Published on November 12, 2010; doi:10.1074/jbc.M110.193722 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Cisplatin Inhibits Protein Splicing, Suggesting Inteins as Therapeutic Targets in Mycobacteria Liyun Zhang, Yuchuan Zheng, Brian Callahan, Marlene Belfort, and Yangzhong Liu
J. Biol. Chem. 2011 286: 1277-1282. First Published on November 8, 2010; doi:10.1074/jbc.M110.171124 [Abstract] [Full Text] [PDF] [Supplemental File (.pdf, 233 KB)]  

Role of a GAG Hinge in the Nucleotide-induced Conformational Change Governing Nucleotide Specificity by T7 DNA Polymerase Zhinan Jin and Kenneth A. Johnson
J. Biol. Chem. 2011 286: 1312-1322. First Published on October 26, 2010; doi:10.1074/jbc.M110.156737 [Abstract] [Full Text] [PDF]  

Activated Protein C N-Linked Glycans Modulate Cytoprotective Signaling Function on Endothelial Cells Fionnuala Ní Áinle, James S. O'Donnell, Jennifer A. Johnson, Laura Brown, Eimear M. Gleeson, Owen P. Smith, and Roger J. S. Preston
J. Biol. Chem. 2011 286: 1323-1330. First Published on November 2, 2010; doi:10.1074/jbc.M110.159475 [Abstract] [Full Text] [PDF] [SUPPLEMENTAL FIGURES (.pdf, 302 KB)]  

Molybdopterin Dinucleotide Biosynthesis in Escherichia coli: IDENTIFICATION OF AMINO ACID RESIDUES OF MOLYBDOPTERIN DINUCLEOTIDE TRANSFERASES THAT DETERMINE SPECIFICITY FOR BINDING OF GUANINE OR CYTOSINE NUCLEOTIDES Meina Neumann, Farida Seduk, Chantal Iobbi-Nivol, and Silke Leimkühler
J. Biol. Chem. 2011 286: 1400-1408. First Published on November 16, 2010; doi:10.1074/jbc.M110.155671 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Regulated Phosphorylation of a Major UDP-glucuronosyltransferase Isozyme by Tyrosine Kinases Dictates Endogenous Substrate Selection for Detoxification Partha S. Mitra, Nikhil K. Basu, Mousumi Basu, Sunit Chakraborty, Tapas Saha, and Ida S. Owens
J. Biol. Chem. 2011 286: 1639-1648. First Published on November 5, 2010; doi:10.1074/jbc.M110.165126 [Abstract] [Full Text] [PDF] [TEXT AND FIGURE (.pdf, 218 KB)] AUTHOR'S CHOICE  

 

Gene Regulation

 STAT1 Is a Master Regulator of Pancreatic β-Cell Apoptosis and Islet Inflammation Fabrice Moore, Najib Naamane, Maikel L. Colli, Thomas Bouckenooghe, Fernanda Ortis, Esteban N. Gurzov, Mariana Igoillo-Esteve, Chantal Mathieu, Gianluca Bontempi, Thomas Thykjaer, Torben F. Ørntoft, and Decio L. Eizirik
J. Biol. Chem. 2011 286: 929-941. First Published on October 27, 2010; doi:10.1074/jbc.M110.162131 [Abstract] [Full Text] [PDF] [Supplemental Data (.xls, 8.0 MB)]  

Calcineurin/Nuclear Factor of Activated T Cells and MAPK Signaling Induce TNF- Gene Expression in Pancreatic Islet Endocrine Cells Michael C. Lawrence, Bashoo Naziruddin, Marlon F. Levy, Andrew Jackson, and Kathleen McGlynn
J. Biol. Chem. 2011 286: 1025-1036. First Published on November 8, 2010; doi:10.1074/jbc.M110.158675 [Abstract] [Full Text] [PDF]  

Sall1 Regulates Embryonic Stem Cell Differentiation in Association with Nanog Efthimia Karantzali, Vassilios Lekakis, Marilia Ioannou, Christiana Hadjimichael, Joseph Papamatheakis, and Androniki Kretsovali J. Biol. Chem. 2011 286: 1037-1045. First Published on November 9, 2010; doi:10.1074/jbc.M110.170050 [Abstract] [Full Text] [PDF] [supplement data (.pdf, 270 KB)] AUTHOR'S CHOICE  


Recruitment of RelB to the Csf2 Promoter Enhances RelA-mediated Transcription of Granulocyte-Macrophage Colony-stimulating Factor Carl Y. Sasaki, Paritosh Ghosh, and Dan L. Longo
J. Biol. Chem. 2011 286: 1093-1102. First Published on November 11, 2010; doi:10.1074/jbc.M110.119438 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Insights into Association of the NuRD Complex with FOG-1 from the Crystal Structure of an RbAp48·FOG-1 Complex Sara Lejon, Sock Yue Thong, Andal Murthy, Saad AlQarni, Natalia V. Murzina, Gerd A. Blobel, Ernest D. Laue, and Joel P. Mackay
J. Biol. Chem. 2011 286: 1196-1203. First Published on November 2, 2010; doi:10.1074/jbc.M110.195842 [Abstract] [Full Text] [PDF] [Supplemental Figure 1 (.pdf, 56 KB)] AUTHOR'S CHOICE  


Human Glycolipid Transfer Protein Gene (GLTP) Expression Is Regulated by Sp1 and Sp3: INVOLVEMENT OF THE BIOACTIVE SPHINGOLIPID CERAMIDE Xianqiong Zou, Yongguang Gao, Vivian R. Ruvolo, Tawnya L. Gardner, Peter P. Ruvolo, and Rhoderick E. Brown
J. Biol. Chem. 2011 286: 1301-1311. First Published on October 25, 2010; doi:10.1074/jbc.M110.127837 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Additional Sex Comb-like (ASXL) Proteins 1 and 2 Play Opposite Roles in Adipogenesis via Reciprocal Regulation of Peroxisome Proliferator-activated Receptor  Ui-Hyun Park, Seung Kew Yoon, Taesun Park, Eun-Joo Kim, and Soo-Jong Um
J. Biol. Chem. 2011 286: 1354-1363. First Published on November 3, 2010; doi:10.1074/jbc.M110.177816 [Abstract] [Full Text] [PDF] [Supplemental Figure 1 (.pdf, 131 KB)]  

Aberrant Estrogen Regulation of PEMT Results in Choline Deficiency-associated Liver Dysfunction Mary E. Resseguie, Kerry-Ann da Costa, Joseph A. Galanko, Mukund Patel, Ian J. Davis, and Steven H. Zeisel
J. Biol. Chem. 2011 286: 1649-1658. First Published on November 8, 2010; doi:10.1074/jbc.M110.106922 [Abstract] [Full Text] [PDF] [Supplemental Data]  


Glycobiology and Extracellular Matrices

 Lysyl Oxidase-like-2 (LOXL2) Is a Major Isoform in Chondrocytes and Is Critically Required for Differentiation Mussadiq Iftikhar, Paola Hurtado, Manish V. Bais, Nate Wigner, Danielle N. Stephens, Louis C. Gerstenfeld, and Philip C. Trackman
J. Biol. Chem. 2011 286: 909-918. First Published on November 11, 2010; doi:10.1074/jbc.M110.155622 [Abstract] [Full Text] [PDF] [Supplemental Data]  

V3 Versican Isoform Alters the Behavior of Human Melanoma Cells by Interfering with CD44/ErbB-dependent Signaling Daniel Hernández, Laia Miquel-Serra, María-José Docampo, Anna Marco-Ramell, Jennifer Cabrera, Angels Fabra, and Anna Bassols
J. Biol. Chem. 2011 286: 1475-1485. First Published on November 15, 2010; doi:10.1074/jbc.M110.127522 [Abstract] [Full Text] [PDF]  


Immunology

 Inhibition of Suppressive T Cell Factor 1 (TCF-1) Isoforms in Naive CD4+ T Cells Is Mediated by IL-4/STAT6 Signaling Elisabeth Maier, Daniel Hebenstreit, Gernot Posselt, Peter Hammerl, Albert Duschl, and Jutta Horejs-Hoeck
J. Biol. Chem. 2011 286: 919-928. First Published on October 27, 2010; doi:10.1074/jbc.M110.144949 [Abstract] [Full Text] [PDF]  

Xanthine Oxidoreductase Promotes the Inflammatory State of Mononuclear Phagocytes through Effects on Chemokine Expression, Peroxisome Proliferator-activated Receptor- Sumoylation, and HIF-1 Sophie Gibbings, Nancy D. Elkins, Hillary Fitzgerald, Janice Tiao, Mari E. Weyman, Gayle Shibao, Mehdi A. Fini, and Richard M. Wright
J. Biol. Chem. 2011 286: 961-975. First Published on November 8, 2010; doi:10.1074/jbc.M110.150847 [Abstract] [Full Text] [PDF]  

Lineage-specific Effects of 1,25-Dihydroxyvitamin D3 on the Development of Effector CD4 T Cells Matthew T. Palmer, Yun Kyung Lee, Craig L. Maynard, James R. Oliver, Daniel D. Bikle, Anton M. Jetten, and Casey T. Weaver
J. Biol. Chem. 2011 286: 997-1004. First Published on November 3, 2010; doi:10.1074/jbc.M110.163790 [Abstract] [Full Text] [PDF] [Supplemental Data (.pdf, 3.6 MB)]  

Characterization of an Interferon-stimulated Response Element (ISRE) in the Il23a Promoter Shehzad Z. Sheikh, Taku Kobayashi, Katsuyoshi Matsuoka, Joseph C. Onyiah, and Scott E. Plevy
J. Biol. Chem. 2011 286: 1174-1180. First Published on November 21, 2010; doi:10.1074/jbc.M110.147884 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Two Human MYD88 Variants, S34Y and R98C, Interfere with MyD88-IRAK4-Myddosome Assembly Julie George, Precious G. Motshwene, Hui Wang, Andriy V. Kubarenko, Anna Rautanen, Tara C. Mills, Adrian V. S. Hill, Nicholas J. Gay, and Alexander N. R. Weber
J. Biol. Chem. 2011 286: 1341-1353. First Published on October 21, 2010; doi:10.1074/jbc.M110.159996 [Abstract] [Full Text] [PDF] [Supplemental Figure S2 (.pdf, 29 KB)] AUTHOR'S CHOICE  


Structural and Functional Characterization of a Highly Specific Serpin in the Insect Innate Immunity Sun Hee Park, Rui Jiang, Shunfu Piao, Bing Zhang, Eun-Hye Kim, Hyun-Mi Kwon, Xiao Ling Jin, Bok Luel Lee, and Nam-Chul Ha
J. Biol. Chem. 2011 286: 1567-1575. First Published on November 3, 2010; doi:10.1074/jbc.M110.144006 [Abstract] [Full Text] [PDF] [Supplemental Data (.pdf, 8 KB)]  


Lipids

N-Myc and SP Regulate Phosphatidylserine Synthase-1 Expression in Brain and Glial Cells Guergana Tasseva, Laura Cole, and Jean E. Vance
J. Biol. Chem. 2011 286: 1061-1073. First Published on November 10, 2010; doi:10.1074/jbc.M110.158709 [Abstract] [Full Text] [PDF] [suppl data (.pdf, 934 KB)]  

Immunochemical Analysis of the Electronegative LDL Subfraction Shows That Abnormal N-terminal Apolipoprotein B Conformation Is Involved in Increased Binding to Proteoglycans Cristina Bancells, Sònia Benítez, Jordi Ordóñez-Llanos, Katariina Öörni, Petri T. Kovanen, Ross W. Milne, and José L. Sánchez-Quesada
J. Biol. Chem. 2011 286: 1125-1133. First Published on November 15, 2010; doi:10.1074/jbc.M110.175315 [Abstract] [Full Text] [PDF] [Supplemental Data]  

DGK1-encoded Diacylglycerol Kinase Activity Is Required for Phospholipid Synthesis during Growth Resumption from Stationary Phase in Saccharomyces cerevisiae Stylianos Fakas, Chrysanthos Konstantinou, and George M. Carman
J. Biol. Chem. 2011 286: 1464-1474. First Published on November 11, 2010; doi:10.1074/jbc.M110.194308 [Abstract] [Full Text] [PDF]  

Phosphorylation of Phosphatidate Phosphatase Regulates Its Membrane Association and Physiological Functions in Saccharomyces cerevisiae: IDENTIFICATION OF SER602, THR723, AND SER744 AS THE SITES PHOSPHORYLATED BY CDC28 (CDK1)-ENCODED CYCLIN-DEPENDENT KINASE Hyeon-Son Choi, Wen-Min Su, Jeanelle M. Morgan, Gil-Soo Han, Zhi Xu, Eleftherios Karanasios, Symeon Siniossoglou, and George M. Carman
J. Biol. Chem. 2011 286: 1486-1498. First Published on November 16, 2010; doi:10.1074/jbc.M110.155598 [Abstract] [Full Text] [PDF]  


Membrane Biology

 Characterization of a Listeria monocytogenes Ca2+ Pump: A SERCA-TYPE ATPase WITH ONLY ONE Ca2+-BINDING SITE Kristina Faxén, Jacob Lauwring Andersen, Pontus Gourdon, Natalya Fedosova, Jens Preben Morth, Poul Nissen, and Jesper Vuust Møller
J. Biol. Chem. 2011 286: 1609-1617. First Published on November 3, 2010; doi:10.1074/jbc.M110.176784 [Abstract] [Full Text] [PDF] [Supplemental figure 1 and 2 (.pdf, 1.9 MB)]  


Metabolism

 The Role of Heme and the Mitochondrion in the Chemical and Molecular Mechanisms of Mammalian Cell Death Induced by the Artemisinin Antimalarials Amy E. Mercer, Ian M. Copple, James L. Maggs, Paul M. O'Neill, and B. Kevin Park
J. Biol. Chem. 2011 286: 987-996. First Published on November 8, 2010; doi:10.1074/jbc.M110.144188 [Abstract] [Full Text] [PDF]  

Aryl Hydrocarbon Receptor Nuclear Translocator/Hypoxia-inducible Factor-1β Plays a Critical Role in Maintaining Glucose-stimulated Anaplerosis and Insulin Release from Pancreatic β-Cells Renjitha Pillai, Peter Huypens, Mei Huang, Stephanie Schaefer, Tanya Sheinin, Shawn D. Wettig, and Jamie W. Joseph
J. Biol. Chem. 2011 286: 1014-1024. First Published on November 8, 2010; doi:10.1074/jbc.M110.149062 [Abstract] [Full Text] [PDF] [Supplemental figures and table (.pdf, 138 KB)]  

Peroxisome Proliferator-activated Receptor  Is Responsible for the Up-regulation of Hepatic Glucose-6-phosphatase Gene Expression in Fasting and db/db Mice Seung-Soon Im, Mi-Young Kim, Sool-Ki Kwon, Tae-Hyun Kim, Jin-Sik Bae, Hail Kim, Kyung-Sup Kim, Goo-Taeg Oh, and Yong-Ho Ahn
J. Biol. Chem. 2011 286: 1157-1164. First Published on November 16, 2010; doi:10.1074/jbc.M110.157875 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Role of Peroxisome Proliferator-activated Receptor /β in Hepatic Metabolic Regulation Sihao Liu, Ben Hatano, Minghui Zhao, Chen-Chung Yen, Kihwa Kang, Shannon M. Reilly, Matthew R. Gangl, Cem Gorgun, James A. Balschi, James M. Ntambi, and Chih-Hao Lee
J. Biol. Chem. 2011 286: 1237-1247. First Published on November 8, 2010; doi:10.1074/jbc.M110.138115 [Abstract] [Full Text] [PDF] [Supplemental Data (.pdf, 860 KB)]  

Overexpression of Glyoxalase-I Reduces Hyperglycemia-induced Levels of Advanced Glycation End Products and Oxidative Stress in Diabetic Rats Olaf Brouwers, Petra M. Niessen, Isabel Ferreira, Toshio Miyata, Peter G. Scheffer, Tom Teerlink, Patrick Schrauwen, Michael Brownlee, Coen D. Stehouwer, and Casper G. Schalkwijk
J. Biol. Chem. 2011 286: 1374-1380. First Published on November 5, 2010; doi:10.1074/jbc.M110.144097 [Abstract] [Full Text] [PDF]  


Microbiology

Selective Sorting of Cargo Proteins into Bacterial Membrane Vesicles M. Florencia Haurat, Joseph Aduse-Opoku, Minnie Rangarajan, Loredana Dorobantu, Murray R. Gray, Michael A. Curtis, and Mario F. Feldman
J. Biol. Chem. 2011 286: 1269-1276. First Published on November 5, 2010; doi:10.1074/jbc.M110.185744 [Abstract] [Full Text] [PDF] [Supplemental data and figures (.pdf, 9.5 MB)]  

Antibacterial Activity of the Contact and Complement Systems Is Blocked by SIC, a Protein Secreted by Streptococcus pyogenes Inga-Maria Frick, Oonagh Shannon, Per Åkesson, Matthias Mörgelin, Mattias Collin, Artur Schmidtchen, and Lars Björck
J. Biol. Chem. 2011 286: 1331-1340. First Published on November 10, 2010; doi:10.1074/jbc.M110.178350 [Abstract] [Full Text] [PDF] AUTHOR'S CHOICE  

 

Molecular Bases of Disease Ligation of Prostate Cancer Cell Surface GRP78 Activates a Proproliferative and Antiapoptotic Feedback Loop: A ROLE FOR SECRETED PROSTATE-SPECIFIC ANTIGEN Uma K. Misra, Sturgis Payne, and Salvatore V. Pizzo
J. Biol. Chem. 2011 286: 1248-1259. First Published on November 5, 2010; doi:10.1074/jbc.M110.129767 [Abstract] [Full Text] [PDF]  

p38 MAPK Activation Is Downstream of the Loss of Intercellular Adhesion in Pemphigus Vulgaris Xuming Mao, Yasuyo Sano, Jin Mo Park, and Aimee S. Payne
J. Biol. Chem. 2011 286: 1283-1291. First Published on November 15, 2010; doi:10.1074/jbc.M110.172874 [Abstract] [Full Text] [PDF] [Supplemental Data]  

MicroRNA-19 (miR-19) Regulates Tissue Factor Expression in Breast Cancer Cells Xiaoxi Zhang, Haijun Yu, Jessica R. Lou, Jie Zheng, Hua Zhu, Narcis-Ioan Popescu, Florea Lupu, Stuart E. Lind, and Wei-Qun Ding
J. Biol. Chem. 2011 286: 1429-1435. First Published on November 8, 2010; doi:10.1074/jbc.M110.146530 [Abstract] [Full Text] [PDF]  

Up-regulation of MicroRNA-155 in Macrophages Contributes to Increased Tumor Necrosis Factor  (TNF) Production via Increased mRNA Half-life in Alcoholic Liver Disease Shashi Bala, Miguel Marcos, Karen Kodys, Timea Csak, Donna Catalano, Pranoti Mandrekar, and Gyongyi Szabo
J. Biol. Chem. 2011 286: 1436-1444. First Published on November 9, 2010; doi:10.1074/jbc.M110.145870 [Abstract] [Full Text] [PDF]  

Cellular and Molecular Mechanisms of Autosomal Dominant Form of Progressive Hearing Loss, DFNA2 Hyo Jeong Kim, Ping Lv, Choong-Ryoul Sihn, and Ebenezer N. Yamoah
J. Biol. Chem. 2011 286: 1517-1527. First Published on October 21, 2010; doi:10.1074/jbc.M110.179010 [Abstract] [Full Text] [PDF] [Supplemental Data (.pdf, 273 KB)]  


Molecular Biophysics

 Characterization of the Oligomeric Structure of the Ca2+-activated Cl– Channel Ano1/TMEM16A John T. Sheridan, Erin N. Worthington, Kuai Yu, Sherif E. Gabriel, H. Criss Hartzell, and Robert Tarran
J. Biol. Chem. 2011 286: 1381-1388. First Published on November 5, 2010; doi:10.1074/jbc.M110.174847 [Abstract] [Full Text] [PDF]  


Neurobiology

 Membrane Cholesterol Modulates β-Amyloid-dependent Tau Cleavage by Inducing Changes in the Membrane Content and Localization of N-Methyl-D-aspartic Acid Receptors Alexandra M. Nicholson, D. Nicole Riherd Methner, and Adriana Ferreira
J. Biol. Chem. 2011 286: 976-986. First Published on November 3, 2010; doi:10.1074/jbc.M110.154138 [Abstract] [Full Text] [PDF] [Supplemental Figures (.pdf, 3.8 MB)]  

Identification of Neuronal RNA Targets of TDP-43-containing Ribonucleoprotein Complexes Chantelle F. Sephton, Can Cenik, Alper Kucukural, Eric B. Dammer, Basar Cenik, YuHong Han, Colleen M. Dewey, Frederick P. Roth, Joachim Herz, Junmin Peng, Melissa J. Moore, and Gang Yu
J. Biol. Chem. 2011 286: 1204-1215. First Published on November 4, 2010; doi:10.1074/jbc.M110.190884 [Abstract] [Full Text] [PDF] [Author profile][Data Files S1_Control_Library (.xlsx, 4.3 MB)] [Summary] AUTHOR'S CHOICE  


Intracellular Regions of the Eag Potassium Channel Play a Critical Role in Generation of Voltage-dependent Currents Yong Li, Xinqiu Liu, Yuying Wu, Zhe Xu, Hongqin Li, Leslie C. Griffith, and Yi Zhou
J. Biol. Chem. 2011 286: 1389-1399. First Published on November 8, 2010; doi:10.1074/jbc.M110.184077 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Partial Biopterin Deficiency Disturbs Postnatal Development of the Dopaminergic System in the Brain Daigo Homma, Chiho Sumi-Ichinose, Hirofumi Tokuoka, Kazuhisa Ikemoto, Takahide Nomura, Kazunao Kondo, Setsuko Katoh, and Hiroshi Ichinose
J. Biol. Chem. 2011 286: 1445-1452. First Published on November 9, 2010; doi:10.1074/jbc.M110.159426 [Abstract] [Full Text] [PDF] [Supplemental Figure 1 (.pdf, 191 KB)]  


Plant Biology

 Nuclear Import and DNA Binding of the ZHD5 Transcription Factor Is Modulated by a Competitive Peptide Inhibitor in Arabidopsis Shin-Young Hong, Ok-Kyoung Kim, Sang-Gyu Kim, Moon-Sik Yang, and Chung-Mo Park
J. Biol. Chem. 2011 286: 1659-1668. First Published on November 8, 2010; doi:10.1074/jbc.M110.167692 [Abstract] [Full Text] [PDF] [Supplemental file (.pdf, 1.1 MB)] AUTHOR'S CHOICE  

 

Protein Structure and Folding

 Strong Cross-bridges Potentiate the Ca2+ Affinity Changes Produced by Hypertrophic Cardiomyopathy Cardiac Troponin C Mutants in Myofilaments: A FAST KINETIC APPROACH Jose Renato Pinto, Daniel P. Reynaldo, Michelle S. Parvatiyar, David Dweck, Jingsheng Liang, Michelle A. Jones, Martha M. Sorenson, and James D. Potter
J. Biol. Chem. 2011 286: 1005-1013. First Published on November 5, 2010; doi:10.1074/jbc.M110.168583 [Abstract] [Full Text] [PDF]  

Crystal Structure of Staphylococcal Enterotoxin G (SEG) in Complex with a Mouse T-cell Receptor β Chain Marisa M. Fernández, Sangwoo Cho, Mauricio C. De Marzi, Melissa C. Kerzic, Howard Robinson, Roy A. Mariuzza, and Emilio L. Malchiodi
J. Biol. Chem. 2011 286: 1189-1195. First Published on November 8, 2010; doi:10.1074/jbc.M110.142471 [Abstract] [Full Text] [PDF]  

Nature of the Ferryl Heme in Compounds I and II Andrea Gumiero, Clive L. Metcalfe, Arwen R. Pearson, Emma Lloyd Raven, and Peter C. E. Moody
J. Biol. Chem. 2011 286: 1260-1268. First Published on November 8, 2010; doi:10.1074/jbc.M110.183483 [Abstract] [Full Text] [PDF]  

Structural Analysis of the Conserved Ubiquitin-binding Motifs (UBMs) of the Translesion Polymerase iota in Complex with Ubiquitin Daniel Burschowsky, Fabian Rudolf, Gwénaël Rabut, Torsten Herrmann, Peter Matthias, and Gerhard Wider
J. Biol. Chem. 2011 286: 1364-1373. First Published on October 6, 2010; doi:10.1074/jbc.M110.135038 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Structure of a Zinc-binding Domain in the Junín Virus Envelope Glycoprotein Klára Briknarová, Celestine J. Thomas, Joanne York, and Jack H. Nunberg
J. Biol. Chem. 2011 286: 1528-1536. First Published on November 10, 2010; doi:10.1074/jbc.M110.166025 [Abstract] [Full Text] [PDF] [Supplemental Information (.pdf, 7.0 MB)]  

Crystal Structure of HugZ, a Novel Heme Oxygenase from Helicobacter pylori Yonglin Hu, Fan Jiang, Ying Guo, Xihui Shen, Ying Zhang, Rui Zhang, Gang Guo, Xuhu Mao, Quanming Zou, and Da-Cheng Wang
J. Biol. Chem. 2011 286: 1537-1544. First Published on October 28, 2010; doi:10.1074/jbc.M110.172007 [Abstract] [Full Text] [PDF]  

Light Chain-dependent Self-association of Dynein Intermediate Chain Afua Nyarko and Elisar Barbar
J. Biol. Chem. 2011 286: 1556-1566. First Published on October 25, 2010; doi:10.1074/jbc.M110.171686 [Abstract] [Full Text] [PDF] [Supplementary figures 1-5 (.pdf, 764 KB)]  

Novel Fold and Carbohydrate Specificity of the Potent Anti-HIV Cyanobacterial Lectin from Oscillatoria agardhii Leonardus M. I. Koharudin, William Furey, and Angela M. Gronenborn
J. Biol. Chem. 2011 286: 1588-1597. First Published on October 19, 2010; doi:10.1074/jbc.M110.173278 [Abstract] [Full Text] [PDF] [Supplemental Data (.pdf, 2.8 MB)]  


Protein Synthesis and Degradation

 Activated Inositol 1,4,5-Trisphosphate Receptors Are Modified by Homogeneous Lys-48- and Lys-63-linked Ubiquitin Chains, but Only Lys-48-linked Chains Are Required for Degradation Danielle A. Sliter, Mike Aguiar, Steven P. Gygi, and Richard J. H. Wojcikiewicz
J. Biol. Chem. 2011 286: 1074-1082. First Published on November 11, 2010; doi:10.1074/jbc.M110.188383 [Abstract] [Full Text] [PDF]  

Mannose Trimming Is Required for Delivery of a Glycoprotein from EDEM1 to XTP3-B and to Late Endoplasmic Reticulum-associated Degradation Steps Bella Groisman, Marina Shenkman, Efrat Ron, and Gerardo Z. Lederkremer
J. Biol. Chem. 2011 286: 1292-1300. First Published on November 9, 2010; doi:10.1074/jbc.M110.154849 [Abstract] [Full Text] [PDF]  


Signal Transduction

 Synergistic Ca2+ Responses by Gi- and Gq-coupled G-protein-coupled Receptors Require a Single PLCβ Isoform That Is Sensitive to Both Gβ and Gq Robert A. Rebres, Tamara I. A. Roach, Iain D. C. Fraser, Finly Philip, Christina Moon, Keng-Mean Lin, Jamie Liu, Leah Santat, Lucas Cheadle, Elliott M. Ross, Melvin I. Simon, and William E. Seaman
J. Biol. Chem. 2011 286: 942-951. First Published on October 29, 2010; doi:10.1074/jbc.M110.198200 [Abstract] [Full Text] [PDF] [Supplemental Figures (.pdf, 102 KB)]  

A CSF-1 Receptor Phosphotyrosine 559 Signaling Pathway Regulates Receptor Ubiquitination and Tyrosine Phosphorylation Ying Xiong, Da Song, Yunfei Cai, Wenfeng Yu, Yee-Guide Yeung, and E. Richard Stanley
J. Biol. Chem. 2011 286: 952-960. First Published on November 1, 2010; doi:10.1074/jbc.M110.166702 [Abstract] [Full Text] [PDF] [Supplemental Figures 1-8 (.pdf, 752 KB)]  

Diminished Paracrine Regulation of the Epithelial Na+ Channel by Purinergic Signaling in Mice Lacking Connexin 30 Elena Mironova, Janos Peti-Peterdi, Vladislav Bugaj, and James D. Stockand
J. Biol. Chem. 2011 286: 1054-1060. First Published on November 12, 2010; doi:10.1074/jbc.M110.176552 [Abstract] [Full Text] [PDF]  

Fluorescence of Phytochrome Adducts with Synthetic Locked Chromophores Benjamin Zienicke, Li-Yi Chen, Htoi Khawn, Mostafa A. S. Hammam, Hideki Kinoshita, Johannes Reichert, Anne S. Ulrich, Katsuhiko Inomata, and Tilman Lamparter
J. Biol. Chem. 2011 286: 1103-1113. First Published on November 11, 2010; doi:10.1074/jbc.M110.155143 [Abstract] [Full Text] [PDF]  

Nimbolide Sensitizes Human Colon Cancer Cells to TRAIL through Reactive Oxygen Species- and ERK-dependent Up-regulation of Death Receptors, p53, and Bax Subash C. Gupta, Simone Reuter, Kanokkarn Phromnoi, Byoungduck Park, Padmanabhan S. Hema, Mangalam Nair, and Bharat B. Aggarwal
J. Biol. Chem. 2011 286: 1134-1146. First Published on November 15, 2010; doi:10.1074/jbc.M110.191379 [Abstract] [Full Text] [PDF]  

Regulatory Effects of Ribosomal S6 Kinase 1 (RSK1) in IFN Signaling Barbara Kroczynska, Sonali Joshi, Elizabeth A. Eklund, Amit Verma, Sergei V. Kotenko, Eleanor N. Fish, and Leonidas C. Platanias
J. Biol. Chem. 2011 286: 1147-1156. First Published on November 12, 2010; doi:10.1074/jbc.M110.183566 [Abstract] [Full Text] [PDF]  

Multiple Scaffolding Functions of β-Arrestins in the Degradation of G Protein-coupled Receptor Kinase 2 Laura Nogués, Alicia Salcedo, Federico Mayor, Jr., and Petronila Penela
J. Biol. Chem. 2011 286: 1165-1173. First Published on November 16, 2010; doi:10.1074/jbc.M110.203406 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Monomeric Rhodopsin Is Sufficient for Normal Rhodopsin Kinase (GRK1) Phosphorylation and Arrestin-1 Binding Timothy H. Bayburt, Sergey A. Vishnivetskiy, Mark A. McLean, Takefumi Morizumi, Chih-chin Huang, John J. G. Tesmer, Oliver P. Ernst, Stephen G. Sligar, and Vsevolod V. Gurevich
J. Biol. Chem. 2011 286: 1420-1428. First Published on October 21, 2010; doi:10.1074/jbc.M110.151043 [Abstract] [Full Text] [PDF] [Supplemental Fig. 1 (.pdf, 864 KB)]  

The Tethering Arm of the EGF Receptor Is Required for Negative Cooperativity and Signal Transduction Sangeeta Adak, Diana DeAndrade, and Linda J. Pike
J. Biol. Chem. 2011 286: 1545-1555. First Published on November 3, 2010; doi:10.1074/jbc.M110.182899 [Abstract] [Full Text] [PDF] [Supplemental figure 2 (.pdf, 1.7 MB)]  

Opposing Actions of Extracellular Signal-regulated Kinase (ERK) and Signal Transducer and Activator of Transcription 3 (STAT3) in Regulating Microtubule Stabilization during Cardiac Hypertrophy Dominic C. H. Ng, Ivan H. W. Ng, Yvonne Y. C. Yeap, Bahareh Badrian, Tatiana Tsoutsman, Julie R. McMullen, Christopher Semsarian, and Marie A. Bogoyevitch
J. Biol. Chem. 2011 286: 1576-1587. First Published on November 5, 2010; doi:10.1074/jbc.M110.128157 [Abstract] [Full Text] [PDF] [Supplemental Data (.pdf, 1.8 MB)]  

Acute Down-regulation of Sodium-dependent Phosphate Transporter NPT2a Involves Predominantly the cAMP/PKA Pathway as Revealed by Signaling-selective Parathyroid Hormone Analogs So Nagai, Makoto Okazaki, Hiroko Segawa, Clemens Bergwitz, Thomas Dean, John T. Potts, Jr, Matthew J. Mahon, Thomas J. Gardella, and Harald Jüppner
J. Biol. Chem. 2011 286: 1618-1626. First Published on November 3, 2010; doi:10.1074/jbc.M110.198416 [Abstract] [Full Text] [PDF] [Supplemental Fig. 1 and Fig. 2 (.pdf, 280 KB)] 

  
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