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:: J. Biol. Chem. Table of Contents for 21 January 2011 ::

Journal of Biological Chemistry Table of Contents Alert
A new issue of Journal of Biological Chemistry is available online: 21 January 2011; Vol. 286, No. 3

The below Table of Contents is available online at:

http://www.jbc.org/content/vol286/issue3/index.dtl?etoc


Papers of the Week

 Initiating Fibril Breakdown: Effect of Tetracyclines on the Dynamics of Formation and Destructuration of β2-Microglobulin Amyloid Fibrils
J. Biol. Chem. 2011 286: e99905. First Published ; doi:10.1074/jbc.P110.178376

Desmosome Dancing Partners: Membrane-impermeable Cross-linking Provides Evidence for Homophilic, Isoform-specific Binding of Desmosomal Cadherins in Epithelial Cells
J. Biol. Chem. 2011 286: e99906. First Published ; doi:10.1074/jbc.P110.192245 [

New Tricks for an Old Antibiotic: Structure and Function of APH(4)-Ia, a Hygromycin B Resistance Enzyme
J. Biol. Chem. 2011 286: e99907. First Published ; doi:10.1074/jbc.P110.194266  



Reflections

Stents, Statins, and Other Dumb Luck Phil Robbins
J. Biol. Chem. 2011 286: 1669-1674. First Published on November 23, 2010; doi:10.1074/jbc.X110.205633 


Classics

 The Process of Reversible Phosphorylation: the Work of Edmond H. Fischer: Edmond H. Fischer was awarded the 1992 Nobel Prize in Physiology or Medicine for his joint research with Edwin G. Krebs on reversible protein phosphorylation. The two Classics reprinted here relate some of Fischer and Krebs' early discoveries in their phosphorylase research Nicole Kresge, Robert D. Simoni, and Robert L. Hill
J. Biol. Chem. 2011 286: e1-2. First Published ; doi:10.1074/jbc.O110.000242 [Full Text]  


Letters to the Editor

 The Role of MafA in Regulating Cytokine Expression in Pancreatic β Cells Nathan L Vanderford
J. Biol. Chem. 2011 286: le1. First Published ; doi:10.1074/jbc.L110.158675 [Full Text] [PDF]  

Response to Vanderford: Control of TNF- Expression in β Cells by MafA Michael C. Lawrence, Bashoo Naziruddin, Marlon F. Levy, Andrew Jackson, and Kathleen McGlynn
J. Biol. Chem. 2011 286: le2. First Published ; doi:10.1074/jbc.N110.158675 [Full Text] [PDF]  

Curcumin and Alzheimer Disease: This Marriage Is Not to Be Performed Cesare Mancuso, Raffaella Siciliano, and Eugenio Barone
J. Biol. Chem. 2011 286: le3. First Published ; doi:10.1074/jbc.L110.133520 [Full Text] [PDF]  

Response to Mancuso et al.: Curcumin and Alzheimer Disease: This Marriage Is Not to Be Performed Can Zhang and Rudolph E. Tanzi
J. Biol. Chem. 2011 286: le4. First Published ; doi:10.1074/jbc.N110.133520 [Full Text] [PDF]  


Cell Biology

Intracellular Acidification Is Associated with Changes in Free Cytosolic Calcium and Inhibition of Action Potentials in Rat Trigeminal Ganglion Sung-Min Hwang, Na-Youn Koo, Meihong Jin, Alexander J. Davies, Gae-Sig Chun, Se-Young Choi, Joong-Soo Kim, and Kyungpyo Park
J. Biol. Chem. 2011 286: 1719-1729. First Published on November 10, 2010; doi:10.1074/jbc.M109.090951 [Abstract] [Full Text] [PDF]  

Calcium-sensing Receptor Decreases Cell Surface Expression of the Inwardly Rectifying K+ Channel Kir4.1 Seung-Kuy Cha, Chunfa Huang, Yaxian Ding, Xiaoping Qi, Chou-Long Huang, and R. Tyler Miller
J. Biol. Chem. 2011 286: 1828-1835. First Published on November 17, 2010; doi:10.1074/jbc.M110.160390 [Abstract] [Full Text] [PDF]  

Tests of Integrin Transmembrane Domain Homo-oligomerization during Integrin Ligand Binding and Signaling Wei Wang, Jieqing Zhu, Timothy A. Springer, and Bing-Hao Luo
J. Biol. Chem. 2011 286: 1860-1867. First Published on November 16, 2010; doi:10.1074/jbc.M110.193797 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Engineered Annexin A5 Variants Have Impaired Cell Entry for Molecular Imaging of Apoptosis Using Pretargeting Strategies Lisette Ungethüm, Heidi Kenis, Gerry A. Nicolaes, Ludovic Autin, Svetla Stoilova-McPhie, and Chris P. M. Reutelingsperger
J. Biol. Chem. 2011 286: 1903-1910. First Published on November 15, 2010; doi:10.1074/jbc.M110.163527 [Abstract] [Full Text] [PDF]  

RioK1, a New Interactor of Protein Arginine Methyltransferase 5 (PRMT5), Competes with pICln for Binding and Modulates PRMT5 Complex Composition and Substrate Specificity Gernot Guderian, Christoph Peter, Julia Wiesner, Albert Sickmann, Klaus Schulze-Osthoff, Utz Fischer, and Matthias Grimmler
J. Biol. Chem. 2011 286: 1976-1986. First Published on November 16, 2010; doi:10.1074/jbc.M110.148486 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Low Cholesterol Triggers Membrane Microdomain-dependent CD44 Shedding and Suppresses Tumor Cell Migration Toshiyuki Murai, Yuusuke Maruyama, Kazuhiro Mio, Hidetoshi Nishiyama, Mitsuo Suga, and Chikara Sato
J. Biol. Chem. 2011 286: 1999-2007. First Published on November 17, 2010; doi:10.1074/jbc.M110.184010 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Myosin Binding Protein C Interaction with Actin: CHARACTERIZATION AND MAPPING OF THE BINDING SITE Inna N. Rybakova, Marion L. Greaser, and Richard L. Moss
J. Biol. Chem. 2011 286: 2008-2016. First Published on November 11, 2010; doi:10.1074/jbc.M110.170605 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Conservation and Diversification of Dileucine Signal Recognition by Adaptor Protein (AP) Complex Variants Rafael Mattera, Markus Boehm, Rittik Chaudhuri, Yogikala Prabhu, and Juan S. Bonifacino
J. Biol. Chem. 2011 286: 2022-2030. First Published on November 19, 2010; doi:10.1074/jbc.M110.197178 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Somatic Cell Plasticity and Niemann-Pick Type C2 Protein: FIBROBLAST ACTIVATION Chad Csepeggi, Min Jiang, Fumiaki Kojima, Leslie J. Crofford, and Andrey Frolov
J. Biol. Chem. 2011 286: 2078-2087. First Published on November 17, 2010; doi:10.1074/jbc.M110.135897 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Cell Fate Determination Factor Dachshund Reprograms Breast Cancer Stem Cell Function Kongming Wu, Xuanmao Jiao, Zhaoming Li, Sanjay Katiyar, Mathew C. Casimiro, Wancai Yang, Qiong Zhang, Nicole E. Willmarth, Iouri Chepelev, Marco Crosariol, Zhang Wei, Junbo Hu, Keji Zhao, and Richard G. Pestell
J. Biol. Chem. 2011 286: 2132-2142. First Published on October 11, 2010; doi:10.1074/jbc.M110.148395 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Membrane-impermeable Cross-linking Provides Evidence for Homophilic, Isoform-specific Binding of Desmosomal Cadherins in Epithelial Cells Zhuxiang Nie, Anita Merritt, Mansour Rouhi-Parkouhi, Lydia Tabernero, and David Garrod
J. Biol. Chem. 2011 286: 2143-2154. First Published on November 22, 2010; doi:10.1074/jbc.M110.192245 [Abstract] [Full Text] [PDF] [Author profile][Supplemental Data] [Summary]  

Identification of Residues within Tropomodulin-1 Responsible for Its Localization at the Pointed Ends of the Actin Filaments in Cardiac Myocytes Takehiro Tsukada, Lucy Kotlyanskaya, Robert Huynh, Brinda Desai, Stefanie M. Novak, Andrey V. Kajava, Carol C. Gregorio, and Alla S. Kostyukova
J. Biol. Chem. 2011 286: 2194-2204. First Published on November 15, 2010; doi:10.1074/jbc.M110.186924 [Abstract] [Full Text] [PDF]  

The Yeast Homolog of Heme Oxygenase-1 Affords Cellular Antioxidant Protection via the Transcriptional Regulation of Known Antioxidant Genes Emma J. Collinson, Sabine Wimmer-Kleikamp, Sebastien K. Gerega, Yee Hwa Yang, Christopher R. Parish, Ian W. Dawes, and Roland Stocker
J. Biol. Chem. 2011 286: 2205-2214. First Published on November 16, 2010; doi:10.1074/jbc.M110.187062 [Abstract] [Full Text] [PDF] [Supplemental Data]  

 

Aurora B Interacts with NIR-p53, Leading to p53 Phosphorylation in Its DNA-binding Domain and Subsequent Functional Suppression Liming Wu, Chi A. Ma, Yongge Zhao, and Ashish Jain
J. Biol. Chem. 2011 286: 2236-2244. First Published on October 19, 2010; doi:10.1074/jbc.M110.174755 [Abstract] [Full Text] [PDF] [Supplemental data (.pdf, 298 KB)]  

Transducer of Cdc42-dependent Actin Assembly Promotes Epidermal Growth Factor-induced Cell Motility and Invasiveness Jinghui Hu, Alka Mukhopadhyay, and Andrew W. B. Craig
J. Biol. Chem. 2011 286: 2261-2272. First Published on November 9, 2010; doi:10.1074/jbc.M110.157974 [Abstract] [Full Text] [PDF] [Supplemental Figure 2 (.jpg, 117 KB)] 

 

Keratin Hypersumoylation Alters Filament Dynamics and Is a Marker for Human Liver Disease and Keratin Mutation Natasha T. Snider, Sujith V. W. Weerasinghe, Jorge A. Iñiguez-Lluhí, Harald Herrmann, and M. Bishr Omary
J. Biol. Chem. 2011 286: 2273-2284. First Published on November 9, 2010; doi:10.1074/jbc.M110.171314 [Abstract] [Full Text] [PDF] [Supplemental Figures and Legends (.pdf, 449 KB)]  


Enzymology

 Analysis of the Polymerization Initiation and Activity of Pasteurella multocida Heparosan Synthase PmHS2, an Enzyme with Glycosyltransferase and UDP-sugar Hydrolase Activity Anais A. E. Chavaroche, Lambertus A. M. van den Broek, Jan Springer, Carmen Boeriu, and Gerrit Eggink
J. Biol. Chem. 2011 286: 1777-1785. First Published on November 17, 2010; doi:10.1074/jbc.M110.136754 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Basic Tetrapeptides as Potent Intracellular Inhibitors of Type A Botulinum Neurotoxin Protease Activity Martha Hale, George Oyler, Subramanyam Swaminathan, and S. Ashraf Ahmed
J. Biol. Chem. 2011 286: 1802-1811. First Published on October 20, 2010; doi:10.1074/jbc.M110.146464 [Abstract] [Full Text] [PDF]  

Chymotrypsin C Is a Co-activator of Human Pancreatic Procarboxypeptidases A1 and A2 Richárd Szmola, Melinda Bence, Andrea Carpentieri, András Szabó, Catherine E. Costello, John Samuelson, and Miklós Sahin-Tóth
J. Biol. Chem. 2011 286: 1819-1827. First Published on November 22, 2010; doi:10.1074/jbc.M110.187369 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Structure and Catalysis of Acylaminoacyl Peptidase: CLOSED AND OPEN SUBUNITS OF A DIMER OLIGOPEPTIDASE Veronika Harmat, Klarissza Domokos, Dóra K. Menyhárd, Anna Palló, Zoltán Szeltner, Ilona Szamosi, Tamás Beke-Somfai, Gábor Náray-Szabó, and László Polgár
J. Biol. Chem. 2011 286: 1987-1998. First Published on November 16, 2010; doi:10.1074/jbc.M110.169862 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Characterization of the Elongation Complex of Dengue Virus RNA Polymerase: ASSEMBLY, KINETICS OF NUCLEOTIDE INCORPORATION, AND FIDELITY Zhinan Jin, Jerome Deval, Kenneth A. Johnson, and David C. Swinney
J. Biol. Chem. 2011 286: 2067-2077. First Published on November 15, 2010; doi:10.1074/jbc.M110.162685 [Abstract] [Full Text] [PDF] [Supplemental Data] AUTHOR'S CHOICE  


Cut-like Homeobox 1 (CUX1) Regulates Expression of the Fat Mass and Obesity-associated and Retinitis Pigmentosa GTPase Regulator-interacting Protein-1-like (RPGRIP1L) Genes and Coordinates Leptin Receptor Signaling George Stratigopoulos, Charles A. LeDuc, Maria L. Cremona, Wendy K. Chung, and Rudolph L. Leibel
J. Biol. Chem. 2011 286: 2155-2170. First Published on October 31, 2010; doi:10.1074/jbc.M110.188482 [Abstract] [Full Text] [PDF] [Supplemental Table 1 (.pdf, 337 KB)]  


Gene Regulation

ThnY Is a Ferredoxin Reductase-like Iron-Sulfur Flavoprotein That Has Evolved to Function as a Regulator of Tetralin Biodegradation Gene Expression Laura Ledesma García, Elena Rivas-Marín, Belén Floriano, Rita Bernhardt, Kerstin Maria Ewen, Francisca Reyes-Ramírez, and Eduardo Santero
J. Biol. Chem. 2011 286: 1709-1718. First Published on November 10, 2010; doi:10.1074/jbc.M110.184648 [Abstract] [Full Text] [PDF]  

PARP-14 Functions as a Transcriptional Switch for Stat6-dependent Gene Activation Purvi Mehrotra, Jonathan P. Riley, Ravi Patel, Fang Li, Le'erin Voss, and Shreevrat Goenka
J. Biol. Chem. 2011 286: 1767-1776. First Published on November 16, 2010; doi:10.1074/jbc.M110.157768 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Inhibition of Proprotein Convertase SKI-1 Blocks Transcription of Key Extracellular Matrix Genes Regulating Osteoblastic Mineralization Jeff P. Gorski, Nichole T. Huffman, Sridar Chittur, Ronald J. Midura, Claudine Black, Julie Oxford, and Nabil G. Seidah
J. Biol. Chem. 2011 286: 1836-1849. First Published on November 12, 2010; doi:10.1074/jbc.M110.151647 [Abstract] [Full Text] [PDF]  

The Actin-binding Protein, Actinin Alpha 4 (ACTN4), Is a Nuclear Receptor Coactivator that Promotes Proliferation of MCF-7 Breast Cancer Cells Simran Khurana, Sharmistha Chakraborty, Xiwen Cheng, Yu-Ting Su, and Hung-Ying Kao
J. Biol. Chem. 2011 286: 1850-1859. First Published on November 15, 2010; doi:10.1074/jbc.M110.162107 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Salmonella enterica Response Regulator SsrB Relieves H-NS Silencing by Displacing H-NS Bound in Polymerization Mode and Directly Activates Transcription Don Walthers, You Li, Yingjie Liu, Ganesh Anand, Jie Yan, and Linda J. Kenney
J. Biol. Chem. 2011 286: 1895-1902. First Published on November 8, 2010; doi:10.1074/jbc.M110.164962 [Abstract] [Full Text] [PDF] [Supplemental Table and Figures (.pdf, 243 KB)]  

Histone Deacetylase 9 Activates -Globin Gene Expression in Primary Erythroid Cells Shalini A. Muralidhar, Valya Ramakrishnan, Inderdeep S. Kalra, Wei Li, and Betty S. Pace
J. Biol. Chem. 2011 286: 2343-2353. First Published on November 13, 2010; doi:10.1074/jbc.M110.115725 [Abstract] [Full Text] [PDF]  


Glycobiology and Extracellular Matrices

 Cooperative Binding and Activation of Fibronectin by a Bacterial Surface Protein Zoe R. Marjenberg, Ian R. Ellis, Robert M. Hagan, Sabitha Prabhakaran, Magnus Höök, Susanne R. Talay, Jennifer R. Potts, David Staunton, and Ulrich Schwarz-Linek
J. Biol. Chem. 2011 286: 1884-1894. First Published on November 8, 2010; doi:10.1074/jbc.M110.183053 [Abstract] [Full Text] [PDF] [Supplemental Information (.pdf, 1.6 MB)]  

Basement Membrane Deposition of Nidogen 1 but Not Nidogen 2 Requires the Nidogen Binding Module of the Laminin 1 Chain Sharada Mokkapati, Anja Fleger-Weckmann, Manuela Bechtel, Manuel Koch, Dirk Breitkreutz, Ulrike Mayer, Neil Smyth, and Roswitha Nischt
J. Biol. Chem. 2011 286: 1911-1918. First Published on November 17, 2010; doi:10.1074/jbc.M110.149864 [Abstract] [Full Text] [PDF]  


Immunology

 Transcriptional Activation of the cAMP-responsive Modulator Promoter in Human T Cells Is Regulated by Protein Phosphatase 2A-mediated Dephosphorylation of SP-1 and Reflects Disease Activity in Patients with Systemic Lupus Erythematosus Yuang-Taung Juang, Thomas Rauen, Ying Wang, Kunihiro Ichinose, Konrad Benedyk, Klaus Tenbrock, and George C. Tsokos
J. Biol. Chem. 2011 286: 1795-1801. First Published on November 19, 2010; doi:10.1074/jbc.M110.166785 [Abstract] [Full Text] [PDF]  

Anti-inflammatory Role of Microsomal Prostaglandin E Synthase-1 in a Model of Neuroinflammation Christian Brenneis, Ovidiu Coste, Kai Altenrath, Carlo Angioni, Helmut Schmidt, Claus-Dieter Schuh, Dong Dong Zhang, Marina Henke, Andreas Weigert, Bernhard Brüne, Barry Rubin, Rolf Nusing, Klaus Scholich, and Gerd Geisslinger
J. Biol. Chem. 2011 286: 2331-2342. First Published on November 12, 2010; doi:10.1074/jbc.M110.157362 [Abstract] [Full Text] [PDF] [Supplemental Data]  


Lipids

Coordination of Storage Lipid Synthesis and Membrane Biogenesis: EVIDENCE FOR CROSS-TALK BETWEEN TRIACYLGLYCEROL METABOLISM AND PHOSPHATIDYLINOSITOL SYNTHESIS Maria L. Gaspar, Harald F. Hofbauer, Sepp D. Kohlwein, and Susan A. Henry
J. Biol. Chem. 2011 286: 1696-1708. First Published on October 23, 2010; doi:10.1074/jbc.M110.172296 [Abstract] [Full Text] [PDF]  


Membrane Biology

Acute Cholesterol-induced Anti-natriuretic Effects: ROLE OF EPITHELIAL Na+ CHANNEL ACTIVITY, PROTEIN LEVELS, AND PROCESSING Mouhamed S. Awayda, Karen L. Awayda, Oleh Pochynyuk, Vladislav Bugaj, James D. Stockand, and Rudy M. Ortiz
J. Biol. Chem. 2011 286: 1683-1695. First Published on November 1, 2010; doi:10.1074/jbc.M110.159194 [Abstract] [Full Text] [PDF] [Supplemental Fig.1 (.pdf, 333 KB)]  

Envelope Lipid-packing as a Critical Factor for the Biological Activity and Stability of Alphavirus Particles Isolated from Mammalian and Mosquito Cells Ivanildo P. Sousa, Jr, Carlos A. M. Carvalho, Davis F. Ferreira, Gilberto Weissmüller, Gustavo M. Rocha, Jerson L. Silva, and Andre M. O. Gomes
J. Biol. Chem. 2011 286: 1730-1736. First Published on November 12, 2010; doi:10.1074/jbc.M110.198002 [Abstract] [Full Text] [PDF] [Supplemental Data]  

The Sphingosine 1-Phosphate Transporter, SPNS2, Functions as a Transporter of the Phosphorylated Form of the Immunomodulating Agent FTY720 Yu Hisano, Naoki Kobayashi, Atsuo Kawahara, Akihito Yamaguchi, and Tsuyoshi Nishi
J. Biol. Chem. 2011 286: 1758-1766. First Published on November 17, 2010; doi:10.1074/jbc.M110.171116 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Regulation of Glial Glutamate Transporters by C-terminal Domains Ariane Leinenweber, Jan-Philipp Machtens, Birgit Begemann, and Christoph Fahlke
J. Biol. Chem. 2011 286: 1927-1937. First Published on November 19, 2010; doi:10.1074/jbc.M110.153486 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Characterization of a Binding Site for Anionic Phospholipids on KCNQ1 Alison M. Thomas, Stephen C. Harmer, Tapsi Khambra, and Andrew Tinker
J. Biol. Chem. 2011 286: 2088-2100. First Published on November 17, 2010; doi:10.1074/jbc.M110.153551 [Abstract] [Full Text] [PDF]  

TMEM16A Inhibitors Reveal TMEM16A as a Minor Component of Calcium-activated Chloride Channel Conductance in Airway and Intestinal Epithelial Cells Wan Namkung, Puay-Wah Phuan, and A. S. Verkman
J. Biol. Chem. 2011 286: 2365-2374. First Published on November 17, 2010; doi:10.1074/jbc.M110.175109 [Abstract] [Full Text] [PDF] [Supplemental Data]  


Microbiology

Structure and Function of APH(4)-Ia, a Hygromycin B Resistance Enzyme Peter J. Stogios, Tushar Shakya, Elena Evdokimova, Alexei Savchenko, and Gerard D. Wright
J. Biol. Chem. 2011 286: 1966-1975. First Published on November 17, 2010; doi:10.1074/jbc.M110.194266 [Abstract] [Full Text] [PDF] [Author profile][Author profile][Supplemental Data] [Summary]  

Deciphering the Roles of Outer Membrane Protein A Extracellular Loops in the Pathogenesis of Escherichia coli K1 Meningitis Rahul Mittal, Subramanian Krishnan, Ignacio Gonzalez-Gomez, and Nemani V. Prasadarao
J. Biol. Chem. 2011 286: 2183-2193. First Published on November 11, 2010; doi:10.1074/jbc.M110.178236 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Identification and Characterization of a Novel-type Ferric Siderophore Reductase from a Gram-positive Extremophile Marcus Miethke, Antonio J. Pierik, Florian Peuckert, Andreas Seubert, and Mohamed A. Marahiel
J. Biol. Chem. 2011 286: 2245-2260. First Published on November 4, 2010; doi:10.1074/jbc.M110.192468 [Abstract] [Full Text] [PDF]  


Molecular Bases of Disease

Paired Immunoglobulin-like Receptor B Knockout Does Not Enhance Axonal Regeneration or Locomotor Recovery after Spinal Cord Injury Yuka Nakamura, Yuki Fujita, Masaki Ueno, Toshiyuki Takai, and Toshihide Yamashita
J. Biol. Chem. 2011 286: 1876-1883. First Published on November 18, 2010; doi:10.1074/jbc.M110.163493 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Functional Dissection of LIS1 and NDEL1 Towards Understanding the Molecular Mechanisms of Cytoplasmic Dynein Regulation Takayuki Torisawa, Akiko Nakayama, Ken'ya Furuta, Masami Yamada, Shinji Hirotsune, and Yoko Y. Toyoshima
J. Biol. Chem. 2011 286: 1959-1965. First Published on October 29, 2010; doi:10.1074/jbc.M110.169847 [Abstract] [Full Text] [PDF] [Supplemental Movie 5 (.mov, 252 KB)]  

 

Eriodictyol Inhibits RSK2-ATF1 Signaling and Suppresses EGF-induced Neoplastic Cell Transformation Kangdong Liu, Yong-Yeon Cho, Ke Yao, Janos Nadas, Dong Joon Kim, Eun-Jin Cho, Mee-Hyun Lee, Angelo Pugliese, Jishuai Zhang, Ann M. Bode, Ziming Dong, and Zigang Dong
J. Biol. Chem. 2011 286: 2057-2066. First Published on November 22, 2010; doi:10.1074/jbc.M110.147306 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Tamm-Horsfall Glycoprotein Interacts with Renal Outer Medullary Potassium Channel ROMK2 and Regulates Its Function Aparna Renigunta, Vijay Renigunta, Turgay Saritas, Niels Decher, Kerim Mutig, and Siegfried Waldegger
J. Biol. Chem. 2011 286: 2224-2235. First Published on November 16, 2010; doi:10.1074/jbc.M110.149880 [Abstract] [Full Text] [PDF] [Supplemental Data]  


Molecular Biophysics

 The Inhibition Mechanism of Non-phosphorylated Ser768 in the Regulatory Domain of Cystic Fibrosis Transmembrane Conductance Regulator Guangyu Wang
J. Biol. Chem. 2011 286: 2171-2182. First Published on November 8, 2010; doi:10.1074/jbc.M110.145540 [Abstract] [Full Text] [PDF] [Supplemental Information (.pdf, 169 KB)]  

Evidence That Prestin Has at Least Two Voltage-dependent Steps Kazuaki Homma and Peter Dallos
J. Biol. Chem. 2011 286: 2297-2307. First Published on November 11, 2010; doi:10.1074/jbc.M110.185694 [Abstract] [Full Text] [PDF] [Supplemental Data]  


Neurobiology

 Fractalkine Attenuates Excito-neurotoxicity via Microglial Clearance of Damaged Neurons and Antioxidant Enzyme Heme Oxygenase-1 Expression Mariko Noda, Yukiko Doi, Jianfeng Liang, Jun Kawanokuchi, Yoshifumi Sonobe, Hideyuki Takeuchi, Tetsuya Mizuno, and Akio Suzumura
J. Biol. Chem. 2011 286: 2308-2319. First Published on November 11, 2010; doi:10.1074/jbc.M110.169839 [Abstract] [Full Text] [PDF] [supplemental fig1-5 (.pdf, 1.4 MB)]  


Plant Biology

 Alkoxy-auxins Are Selective Inhibitors of Auxin Transport Mediated by PIN, ABCB, and AUX1 Transporters Etsuko Tsuda, Haibing Yang, Takeshi Nishimura, Yukiko Uehara, Tatsuya Sakai, Masahiko Furutani, Tomokazu Koshiba, Masakazu Hirose, Hiroshi Nozaki, Angus S. Murphy, and Ken-ichiro Hayashi
J. Biol. Chem. 2011 286: 2354-2364. First Published on November 17, 2010; doi:10.1074/jbc.M110.171165 [Abstract] [Full Text] [PDF] [Supplemental Data]  


Protein Structure and Folding

 Cytotoxic Enhancement of a Bispecific Diabody by Format Conversion to Tandem Single-chain Variable Fragment (taFv): THE CASE OF THE hEx3 DIABODY Ryutaro Asano, Keiko Ikoma, Ippei Shimomura, Shintaro Taki, Takeshi Nakanishi, Mitsuo Umetsu, and Izumi Kumagai
J. Biol. Chem. 2011 286: 1812-1818. First Published on November 19, 2010; doi:10.1074/jbc.M110.172957 [Abstract] [Full Text] [PDF]  

Danthron Functions as a Retinoic X Receptor Antagonist by Stabilizing Tetramers of the Receptor Haitao Zhang, Rong Zhou, Li Li, Jing Chen, Lili Chen, Chenjing Li, Hong Ding, Liang Yu, Lihong Hu, Hualiang Jiang, and Xu Shen
J. Biol. Chem. 2011 286: 1868-1875. First Published on November 17, 2010; doi:10.1074/jbc.M110.166215 [Abstract] [Full Text] [PDF]  

Location of Glycine Mutations within a Bacterial Collagen Protein Affects Degree of Disruption of Triple-helix Folding and Conformation Haiming Cheng, Shayan Rashid, Zhuoxin Yu, Ayumi Yoshizumi, Eileen Hwang, and Barbara Brodsky
J. Biol. Chem. 2011 286: 2041-2046. First Published on November 11, 2010; doi:10.1074/jbc.M110.153965 [Abstract] [Full Text] [PDF]  

Effect of Tetracyclines on the Dynamics of Formation and Destructuration of β2-Microglobulin Amyloid Fibrils Sofia Giorgetti, Sara Raimondi, Katiuscia Pagano, Annalisa Relini, Monica Bucciantini, Alessandra Corazza, Federico Fogolari, Luca Codutti, Mario Salmona, Palma Mangione, Lino Colombo, Ada De Luigi, Riccardo Porcari, Alessandra Gliozzi, Massimo Stefani, Gennaro Esposito, Vittorio Bellotti, and Monica Stoppini
J. Biol. Chem. 2011 286: 2121-2131. First Published on November 10, 2010; doi:10.1074/jbc.M110.178376 [Abstract] [Full Text] [PDF] [Author profile][supplemental data (.pdf, 2.1 MB)] [Summary]  

NMR Analyses of the Gβ Binding and Conformational Rearrangements of the Cytoplasmic Pore of G Protein-activated Inwardly Rectifying Potassium Channel 1 (GIRK1) Mariko Yokogawa, Masanori Osawa, Koh Takeuchi, Yoko Mase, and Ichio Shimada
J. Biol. Chem. 2011 286: 2215-2223. First Published on November 12, 2010; doi:10.1074/jbc.M110.160754 [Abstract] [Full Text] [PDF] [Supplemental Data]  

 

Structure of the Escherichia coli Antitoxin MqsA (YgiT/b3021) Bound to Its Gene Promoter Reveals Extensive Domain Rearrangements and the Specificity of Transcriptional Regulation Breann L. Brown, Thomas K. Wood, Wolfgang Peti, and Rebecca Page
J. Biol. Chem. 2011 286: 2285-2296. First Published on November 9, 2010; doi:10.1074/jbc.M110.172643 [Abstract] [Full Text] [PDF] [Supplemental Table and Figures (.pdf, 869 KB)]  


RNA

 The Interleukin 13 (IL-13) Pathway in Human Macrophages Is Modulated by MicroRNA-155 via Direct Targeting of Interleukin 13 Receptor 1 (IL13R1) Rocio T. Martinez-Nunez, Fethi Louafi, and Tilman Sanchez-Elsner
J. Biol. Chem. 2011 286: 1786-1794. First Published on November 19, 2010; doi:10.1074/jbc.M110.169367 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Adenosine-to-Inosine RNA Editing Affects Trafficking of the -Aminobutyric Acid Type A (GABAA) Receptor Chammiran Daniel, Helene Wahlstedt, Johan Ohlson, Petra Björk, and Marie Öhman
J. Biol. Chem. 2011 286: 2031-2040. First Published on October 28, 2010; doi:10.1074/jbc.M110.130096 [Abstract] [Full Text] [PDF] [supplemental figures (.pdf, 582 KB)]  


Signal Transduction

NF-B Down-regulates Expression of the B-lymphoma Marker CD10 through a miR-155/PU.1 Pathway Ryan C. Thompson, Melanie Herscovitch, Ian Zhao, Tyler J. Ford, and Thomas D. Gilmore
J. Biol. Chem. 2011 286: 1675-1682. First Published on October 14, 2010; doi:10.1074/jbc.M110.177063 [Abstract] [Full Text] [PDF] [Supplemental Data (.pdf, 459 KB)]  

KRIBB11 Inhibits HSP70 Synthesis through Inhibition of Heat Shock Factor 1 Function by Impairing the Recruitment of Positive Transcription Elongation Factor b to the hsp70 Promoter Young Ju Yoon, Joo Ae Kim, Ki Deok Shin, Dae-Seop Shin, Young Min Han, Yu Jin Lee, Jin Soo Lee, Byoung-Mog Kwon, and Dong Cho Han
J. Biol. Chem. 2011 286: 1737-1747. First Published on November 15, 2010; doi:10.1074/jbc.M110.179440 [Abstract] [Full Text] [PDF]  

Thr-370 Is Responsible for CDK11p58 Autophosphorylation, Dimerization, and Kinase Activity Yayun Chi, Chunyi Zhang, Hongliang Zong, Yi Hong, Xiangfei Kong, Haiou Liu, Weiying Zou, Yanlin Wang, Xiaojing Yun, and Jianxin Gu
J. Biol. Chem. 2011 286: 1748-1757. First Published on November 15, 2010; doi:10.1074/jbc.M110.107367 [Abstract] [Full Text] [PDF]  

Low Extracellular pH Induces Damage in the Pancreatic Acinar Cell by Enhancing Calcium Signaling Anamika M. Reed, Sohail Z. Husain, Edwin Thrower, Martine Alexandre, Ahsan Shah, Fred S. Gorelick, and Michael H. Nathanson
J. Biol. Chem. 2011 286: 1919-1926. First Published on November 17, 2010; doi:10.1074/jbc.M110.158329 [Abstract] [Full Text] [PDF] [Supplemental Data]  

A Novel Motif in the Crohn's Disease Susceptibility Protein, NOD2, Allows TRAF4 to Down-regulate Innate Immune Responses Jill M. Marinis, Craig R. Homer, Christine McDonald, and Derek W. Abbott
J. Biol. Chem. 2011 286: 1938-1950. First Published on November 19, 2010; doi:10.1074/jbc.M110.189308 [Abstract] [Full Text] [PDF]  

Hyperosmotic Stress-induced ATF-2 Activation through Polo-like Kinase 3 in Human Corneal Epithelial Cells Ling Wang, Reid Payton, Wei Dai, and Luo Lu
J. Biol. Chem. 2011 286: 1951-1958. First Published on November 22, 2010; doi:10.1074/jbc.M110.166009 [Abstract] [Full Text] [PDF]  

Aspartate 141 Is the Fourth Ligand of the Oxygen-sensing [4Fe-4S]2+ Cluster of Bacillus subtilis Transcriptional Regulator Fnr Ines Gruner, Claudia Frädrich, Lars H. Böttger, Alfred X. Trautwein, Dieter Jahn, and Elisabeth Härtig
J. Biol. Chem. 2011 286: 2017-2021. First Published on November 10, 2010; doi:10.1074/jbc.M110.191940 [Abstract] [Full Text] [PDF] [Supplemental Table 1 (.docx, 15 KB)]  

 

miR-200b Targets Ets-1 and Is Down-regulated by Hypoxia to Induce Angiogenic Response of Endothelial Cells Yuk Cheung Chan, Savita Khanna, Sashwati Roy, and Chandan K. Sen
J. Biol. Chem. 2011 286: 2047-2056. First Published on November 16, 2010; doi:10.1074/jbc.M110.158790 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Altered Immune Response in Mice Deficient for the G Protein-coupled Receptor GPR34 Ines Liebscher, Uwe Müller, Daniel Teupser, Eva Engemaier, Kathrin M. Y. Engel, Lars Ritscher, Doreen Thor, Katrin Sangkuhl, Albert Ricken, Antje Wurm, Daniel Piehler, Sandra Schmutzler, Herbert Fuhrmann, Frank W. Albert, Andreas Reichenbach, Joachim Thiery, Torsten Schöneberg, and Angela Schulz
J. Biol. Chem. 2011 286: 2101-2110. First Published on November 19, 2010; doi:10.1074/jbc.M110.196659 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Tumor-secreted PGE2 Inhibits CCL5 Production in Activated Macrophages through cAMP/PKA Signaling Pathway Xuesong Qian, Jidong Zhang, and Jianguo Liu
J. Biol. Chem. 2011 286: 2111-2120. First Published on November 19, 2010; doi:10.1074/jbc.M110.154971 [Abstract] [Full Text] [PDF] [Supplemental Data]  

The MARCKS Protein Plays a Critical Role in Phosphatidylinositol 4,5-Bisphosphate Metabolism and Directed Cell Movement in Vascular Endothelial Cells Hermann Kalwa and Thomas Michel
J. Biol. Chem. 2011 286: 2320-2330. First Published on November 20, 2010; doi:10.1074/jbc.M110.196022 [Abstract] [Full Text] [PDF] [Supplemental Data]  

    

  
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