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:: J. Biol. Chem. Table of Contents for 4 February 2011 ::

Journal of Biological Chemistry Table of Contents Alert
A new issue of Journal of Biological Chemistry is available online: 4 February 2011; Vol. 286, No. 5

The below Table of Contents is available online at: http://www.jbc.org/content/vol286/issue5/index.dtl?etoc


Papers of the Week

Sneaky Staph Can Shed Syndecan-1: Syndecan-1 Promotes Staphylococcus aureus Corneal Infection by Counteracting Neutrophil-mediated Host Defense
J. Biol. Chem. 2011 286: e99910. First Published ; doi:10.1074/jbc.P110.185165 [Full Text] [PDF]  

The Many Faces of E6 Binding: Biophysical Characterization of the Complex between Human Papillomavirus E6 Protein and Synapse-associated Protein 97
J. Biol. Chem. 2011 286: e99911. First Published ; doi:10.1074/jbc.P110.190264 [Full Text] [PDF] [Author profile]  


Minireviews

Cellular Processing of the Glucocorticoid Receptor Gene and Protein: New Mechanisms for Generating Tissue-specific Actions of Glucocorticoids Robert H. Oakley and John A. Cidlowski
J. Biol. Chem. 2011 286: 3177-3184. First Published on December 13, 2010; doi:10.1074/jbc.R110.179325 [Abstract] [Full Text] [PDF] [Author profile]  


Cell Biology

A Membrane-bound Hemoglobin from Gills of the Green Shore Crab Carcinus maenas Beyhan Ertas, Laurent Kiger, Miriam Blank, Michael C. Marden, and Thorsten Burmester
J. Biol. Chem. 2011 286: 3185-3193. First Published on November 29, 2010; doi:10.1074/jbc.M110.160341 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Role of the A20-TRAF6 Axis in Lipopolysaccharide-mediated Osteoclastogenesis Guillaume Mabilleau, Daniel Chappard, and Afsie Sabokbar
J. Biol. Chem. 2011 286: 3242-3249. First Published on December 2, 2010; doi:10.1074/jbc.M110.150300 [Abstract] [Full Text] [PDF]  

B-Crystallin Is Found in Detergent-resistant Membrane Microdomains and Is Secreted via Exosomes from Human Retinal Pigment Epithelial Cells Rajendra K. Gangalum, Ivo C. Atanasov, Z. Hong Zhou, and Suraj P. Bhat
J. Biol. Chem. 2011 286: 3261-3269. First Published on November 19, 2010; doi:10.1074/jbc.M110.160135 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Claudin-2 Forms Homodimers and Is a Component of a High Molecular Weight Protein Complex Christina M. Van Itallie, Laura L. Mitic, and James M. Anderson
J. Biol. Chem. 2011 286: 3442-3450. First Published on November 22, 2010; doi:10.1074/jbc.M110.195578 [Abstract] [Full Text] [PDF] [Supplemental Data]  

A Conserved Motif at the C Terminus of Sororin Is Required for Sister Chromatid Cohesion Frank M. Wu, Judy V. Nguyen, and Susannah Rankin
J. Biol. Chem. 2011 286: 3579-3586. First Published on November 29, 2010; doi:10.1074/jbc.M110.196758 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Activation of Vinculin Induced by Cholinergic Stimulation Regulates Contraction of Tracheal Smooth Muscle Tissue Youliang Huang, Wenwu Zhang, and Susan J. Gunst
J. Biol. Chem. 2011 286: 3630-3644. First Published on November 11, 2010; doi:10.1074/jbc.M110.139923 [Abstract] [Full Text] [PDF] [Supplemental Movie 1 (.mov, 6.1 MB)]  

The Ubiquitin Ligase MYCBP2 Regulates Transient Receptor Potential Vanilloid Receptor 1 (TRPV1) Internalization through Inhibition of p38 MAPK Signaling Sabrina Holland, Ovidiu Coste, Dong Dong Zhang, Sandra C. Pierre, Gerd Geisslinger, and Klaus Scholich
J. Biol. Chem. 2011 286: 3671-3680. First Published on November 23, 2010; doi:10.1074/jbc.M110.154765 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Mitochondrial Targeting of Vitamin E Succinate Enhances Its Pro-apoptotic and Anti-cancer Activity via Mitochondrial Complex II Lan-Feng Dong, Victoria J. A. Jameson, David Tilly, Jiri Cerny, Elahe Mahdavian, Alvaro Marín-Hernández, Luz Hernández-Esquivel, Sara Rodríguez-Enríquez, Jan Stursa, Paul K. Witting, Bela Stantic, Jakub Rohlena, Jaroslav Truksa, Katarina Kluckova, Jeffrey C. Dyason, Miroslav Ledvina, Brian A. Salvatore, Rafael Moreno-Sánchez, Mark J. Coster, Stephen J. Ralph, Robin A. J. Smith, and Jiri Neuzil
J. Biol. Chem. 2011 286: 3717-3728. First Published on November 8, 2010; doi:10.1074/jbc.M110.186643 [Abstract] [Full Text] [PDF] [Supplemental text (.pdf, 81 KB)]  

A Novel Mechanism of Lysosomal Acid Sphingomyelinase Maturation: REQUIREMENT FOR CARBOXYL-TERMINAL PROTEOLYTIC PROCESSING Russell W. Jenkins, Jolanta Idkowiak-Baldys, Fabio Simbari, Daniel Canals, Patrick Roddy, Clarke D. Riner, Christopher J. Clarke, and Yusuf A. Hannun
J. Biol. Chem. 2011 286: 3777-3788. First Published on November 22, 2010; doi:10.1074/jbc.M110.155234 [Abstract] [Full Text] [PDF]  

WAVE2 Forms a Complex with PKA and Is Involved in PKA Enhancement of Membrane Protrusions Hiroshi Yamashita, Kazumitsu Ueda, and Noriyuki Kioka
J. Biol. Chem. 2011 286: 3907-3914. First Published on November 30, 2010; doi:10.1074/jbc.M110.145409 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Role of Np63 in Epithelial to Mesenchymal Transition Jaime Lindsay, Simon S. McDade, Adam Pickard, Karen D. McCloskey, and Dennis J. McCance
J. Biol. Chem. 2011 286: 3915-3924. First Published on December 2, 2010; doi:10.1074/jbc.M110.162511 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Identification and Characterization of the Integrin 2β1 Binding Motif in Chondroadherin Mediating Cell Attachment Lisbet Haglund, Viveka Tillgren, Laura Addis, Christina Wenglén, Anneliese Recklies, and Dick Heinegård
J. Biol. Chem. 2011 286: 3925-3934. First Published on December 2, 2010; doi:10.1074/jbc.M110.161141 [Abstract] [Full Text] [PDF]  

Induction of miR-21 by Retinoic Acid in Estrogen Receptor-positive Breast Carcinoma Cells: BIOLOGICAL CORRELATES AND MOLECULAR TARGETS Mineko Terao, Maddalena Fratelli, Mami Kurosaki, Adriana Zanetti, Valeria Guarnaccia, Gabriela Paroni, Anna Tsykin, Monica Lupi, Maurizio Gianni, Gregory J. Goodall, and Enrico Garattini
J. Biol. Chem. 2011 286: 4027-4042. First Published on December 3, 2010; doi:10.1074/jbc.M110.184994 [Abstract] [Full Text] [PDF] [Supplemental Data]  


Developmental Biology

 The Yb Body, a Major Site for Piwi-associated RNA Biogenesis and a Gateway for Piwi Expression and Transport to the Nucleus in Somatic Cells Hongying Qi, Toshiaki Watanabe, Hsueh-Yen Ku, Na Liu, Mei Zhong, and Haifan Lin
J. Biol. Chem. 2011 286: 3789-3797. First Published on November 24, 2010; doi:10.1074/jbc.M110.193888 [Abstract] [Full Text] [PDF] [Supplemental Data]  


DNA and Chromosomes

 A Novel Non-SET Domain Multi-subunit Methyltransferase Required for Sequential Nucleosomal Histone H3 Methylation by the Mixed Lineage Leukemia Protein-1 (MLL1) Core Complex Anamika Patel, Valarie E. Vought, Venkatasubramanian Dharmarajan, and Michael S. Cosgrove
J. Biol. Chem. 2011 286: 3359-3369. First Published on November 24, 2010; doi:10.1074/jbc.M110.174524 [Abstract] [Full Text] [PDF]  

RBX1 (RING Box Protein 1) E3 Ubiquitin Ligase Is Required for Genomic Integrity by Modulating DNA Replication Licensing Proteins Lijun Jia, Jeremy S. Bickel, Jiaxue Wu, Meredith A. Morgan, Hua Li, Jie Yang, Xiaochun Yu, Raymond C. Chan, and Yi Sun
J. Biol. Chem. 2011 286: 3379-3386. First Published on November 29, 2010; doi:10.1074/jbc.M110.188425 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Molecular Cooperation between the Werner Syndrome Protein and Replication Protein A in Relation to Replication Fork Blockage Amrita Machwe, Enerlyn Lozada, Marc S. Wold, Guo-Min Li, and David K. Orren
J. Biol. Chem. 2011 286: 3497-3508. First Published on November 24, 2010; doi:10.1074/jbc.M110.105411 [Abstract] [Full Text] [PDF] [Supplemental Data] AUTHOR'S CHOICE  

Telomerase Inhibitor PinX1 Provides a Link between TRF1 and Telomerase to Prevent Telomere Elongation Christina Y. Soohoo, Rong Shi, Tae Ho Lee, Pengyu Huang, Kun Ping Lu, and Xiao Zhen Zhou
J. Biol. Chem. 2011 286: 3894-3906. First Published on November 30, 2010; doi:10.1074/jbc.M110.180174 [Abstract] [Full Text] [PDF]  

Specificity of Interactions among the DNA-packaging Machine Components of T4-related Bacteriophages Song Gao and Venigalla B. Rao
J. Biol. Chem. 2011 286: 3944-3956. First Published on December 2, 2010; doi:10.1074/jbc.M110.196907 [Abstract] [Full Text] [PDF]  

Human DNA Polymerase β Mutations Allowing Efficient Abasic Site Bypass Sonja Gieseking, Konrad Bergen, Francesca Di Pasquale, Kay Diederichs, Wolfram Welte, and Andreas Marx
J. Biol. Chem. 2011 286: 4011-4020. First Published on November 24, 2010; doi:10.1074/jbc.M110.176826 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Biophysical Characterization of the Centromere-specific Nucleosome from Budding Yeast Isabel J. Kingston, Jasmine S. Y. Yung, and Martin R. Singleton
J. Biol. Chem. 2011 286: 4021-4026. First Published on November 29, 2010; doi:10.1074/jbc.M110.189340 [Abstract] [Full Text] [PDF]  


Enzymology

Molecular Characterization of a Novel Geranylgeranyl Pyrophosphate Synthase from Plasmodium Parasites Jennifer D. Artz, Amy K. Wernimont, James E. Dunford, Matthieu Schapira, Aiping Dong, Yong Zhao, Jocelyne Lew, R. Graham G. Russell, F. Hal Ebetino, Udo Oppermann, and Raymond Hui
J. Biol. Chem. 2011 286: 3315-3322. First Published on November 17, 2010; doi:10.1074/jbc.M109.027235 [Abstract] [Full Text] [PDF] [Supplemental Data] AUTHOR'S CHOICE  

A New Role for Heme, Facilitating Release of Iron from the Bacterioferritin Iron Biomineral Samina Yasmin, Simon C. Andrews, Geoffrey R. Moore, and Nick E. Le Brun
J. Biol. Chem. 2011 286: 3473-3483. First Published on November 23, 2010; doi:10.1074/jbc.M110.175034 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Thermus thermophilus Glycoside Hydrolase Family 57 Branching Enzyme: CRYSTAL STRUCTURE, MECHANISM OF ACTION, AND PRODUCTS FORMED Marta Palomo, Tjaard Pijning, Thijs Booiman, Justyna M. Dobruchowska, Jeroen van der Vlist, Slavko Kralj, Antoni Planas, Katja Loos, Johannis P. Kamerling, Bauke W. Dijkstra, Marc J. E. C. van der Maarel, Lubbert Dijkhuizen, and Hans Leemhuis
J. Biol. Chem. 2011 286: 3520-3530. First Published on November 19, 2010; doi:10.1074/jbc.M110.179515 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Recognition of Sulfonylurea Receptor (ABCC8/9) Ligands by the Multidrug Resistance Transporter P-glycoprotein (ABCB1): FUNCTIONAL SIMILARITIES BASED ON COMMON STRUCTURAL FEATURES BETWEEN TWO MULTISPECIFIC ABC PROTEINS Anis Bessadok, Elisabeth Garcia, Hélène Jacquet, Solenne Martin, Alexia Garrigues, Nicolas Loiseau, François André, Stéphane Orlowski, and Michel Vivaudou
J. Biol. Chem. 2011 286: 3552-3569. First Published on November 22, 2010; doi:10.1074/jbc.M110.155200 [Abstract] [Full Text] [PDF] [Supplemental Data]  

The Catalytic Aspartate Is Protonated in the Michaelis Complex Formed between Trypsin and an in Vitro Evolved Substrate-like Inhibitor: A REFINED MECHANISM OF SERINE PROTEASE ACTION Weixiao Yuan Wahlgren, Gábor Pál, József Kardos, Pálma Porrogi, Borbála Szenthe, András Patthy, László Gráf, and Gergely Katona
J. Biol. Chem. 2011 286: 3587-3596. First Published on November 21, 2010; doi:10.1074/jbc.M110.161604 [Abstract] [Full Text] [PDF] [Supplemental Data] AUTHOR'S CHOICE  

Distinct Roles of the Active-site Mg2+ Ligands, Asp882 and Asp705, of DNA Polymerase I (Klenow Fragment) during the Prechemistry Conformational Transitions Oya Bermek, Nigel D. F. Grindley, and Catherine M. Joyce
J. Biol. Chem. 2011 286: 3755-3766. First Published on November 16, 2010; doi:10.1074/jbc.M110.167593 [Abstract] [Full Text] [PDF] [Supplemental Data]  


Gene Regulation

Epigenomic Reorganization of the Clustered Hox Genes in Embryonic Stem Cells Induced by Retinoic Acid Vasundhra Kashyap, Lorraine J. Gudas, Fabienne Brenet, Patricia Funk, Agnes Viale, and Joseph M. Scandura
J. Biol. Chem. 2011 286: 3250-3260. First Published on November 18, 2010; doi:10.1074/jbc.M110.157545 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Pregnane X Receptor PXR Activates the GADD45β Gene, Eliciting the p38 MAPK Signal and Cell Migration Susumu Kodama and Masahiko Negishi
J. Biol. Chem. 2011 286: 3570-3578. First Published on December 2, 2010; doi:10.1074/jbc.M110.179812 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Interferon Antagonist NSs of La Crosse Virus Triggers a DNA Damage Response-like Degradation of Transcribing RNA Polymerase II Paul Verbruggen, Marius Ruf, Gjon Blakqori, Anna K. Överby, Martin Heidemann, Dirk Eick, and Friedemann Weber
J. Biol. Chem. 2011 286: 3681-3692. First Published on November 30, 2010; doi:10.1074/jbc.M110.154799 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Heterogeneous Nuclear Ribonucleoprotein H1/H2-dependent Unsplicing of Thymidine Phosphorylase Results in Anticancer Drug Resistance Michal Stark, Eran E. Bram, Martin Akerman, Yael Mandel-Gutfreund, and Yehuda G. Assaraf
J. Biol. Chem. 2011 286: 3741-3754. First Published on November 10, 2010; doi:10.1074/jbc.M110.163444 [Abstract] [Full Text] [PDF] [Supplemental Data (.pdf, 106 KB)]  

Heme Oxygenase-1/Carbon Monoxide Induces Vascular Endothelial Growth Factor Expression via p38 Kinase-dependent Activation of Sp1 Heng-Huei Lin, Shao-Chuan Lai, and Lee-Young Chau
J. Biol. Chem. 2011 286: 3829-3838. First Published on November 28, 2010; doi:10.1074/jbc.M110.168831 [Abstract] [Full Text] [PDF] [Supplemental Data]  


Glycobiology and Extracellular Matrices

 Syndecan-1 Promotes Staphylococcus aureus Corneal Infection by Counteracting Neutrophil-mediated Host Defense Atsuko Hayashida, Shiro Amano, and Pyong Woo Park
J. Biol. Chem. 2011 286: 3288-3297. First Published on December 2, 2010; doi:10.1074/jbc.M110.185165 [Abstract] [Full Text] [PDF] [Summary]  


Immunology

Apoptosis-associated Speck-like Protein (ASC) Controls Legionella pneumophila Infection in Human Monocytes Dalia H. Abdelaziz, Mikhail A. Gavrilin, Anwari Akhter, Kyle Caution, Sheetal Kotrange, Arwa Abu Khweek, Basant A. Abdulrahman, Jaykumar Grandhi, Zeinab A. Hassan, Clay Marsh, Mark D. Wewers, and Amal O. Amer
J. Biol. Chem. 2011 286: 3203-3208. First Published on November 19, 2010; doi:10.1074/jbc.M110.197681 [Abstract] [Full Text] [PDF] [Supplemental Data] AUTHOR'S CHOICE  

UNC93B1 Is Essential for TLR11 Activation and IL-12-dependent Host Resistance to Toxoplasma gondii Reed Pifer, Alicia Benson, Carolyn R. Sturge, and Felix Yarovinsky
J. Biol. Chem. 2011 286: 3307-3314. First Published on November 19, 2010; doi:10.1074/jbc.M110.171025 [Abstract] [Full Text] [PDF] [Supplemental Data]  

LIMP-2 Links Late Phagosomal Trafficking with the Onset of the Innate Immune Response to Listeria monocytogenes: A ROLE IN MACROPHAGE ACTIVATION Eugenio Carrasco-Marín, Lorena Fernández-Prieto, Estela Rodriguez-Del Rio, Fidel Madrazo-Toca, Thomas Reinheckel, Paul Saftig, and Carmen Alvarez-Dominguez
J. Biol. Chem. 2011 286: 3332-3341. First Published on December 1, 2010; doi:10.1074/jbc.M110.146761 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Heterocomplexes of Mannose-binding Lectin and the Pentraxins PTX3 or Serum Amyloid P Component Trigger Cross-activation of the Complement System Ying Jie Ma, Andrea Doni, Mikkel-Ole Skjoedt, Christian Honoré, Maiken Arendrup, Alberto Mantovani, and Peter Garred
J. Biol. Chem. 2011 286: 3405-3417. First Published on November 24, 2010; doi:10.1074/jbc.M110.190637 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Single Domain Intracellular Antibodies from Diverse Libraries: EMPHASIZING DUAL FUNCTIONS OF LMO2 PROTEIN INTERACTIONS USING A SINGLE VH DOMAIN Tomoyuki Tanaka, Helen Sewell, Simon Waters, Simon E. V. Phillips, and Terence H. Rabbitts
J. Biol. Chem. 2011 286: 3707-3716. First Published on October 27, 2010; doi:10.1074/jbc.M110.188193 [Abstract] [Full Text] [PDF] [Supplemental Data]  

The Biosynthesis Characteristics of TTP and TNF Can Be Regulated through a Posttranscriptional Molecular Loop Naveed Aslam and Irum Zaheer
J. Biol. Chem. 2011 286: 3767-3776. First Published on November 18, 2010; doi:10.1074/jbc.M110.168757 [Abstract] [Full Text] [PDF] [Supplemental Data]  

TNF- Induces Macroautophagy and Regulates MHC Class II Expression in Human Skeletal Muscle Cells Christian W. Keller, Claudia Fokken, Stuart G. Turville, Anna Lünemann, Jens Schmidt, Christian Münz, and Jan D. Lünemann
J. Biol. Chem. 2011 286: 3970-3980. First Published on October 27, 2010; doi:10.1074/jbc.M110.159392 [Abstract] [Full Text] [PDF] [Supplemental Data (.pdf, 196 KB)]  


Lipids

Visualization of Lipid Droplet Composition by Direct Organelle Mass Spectrometry Patrick J. Horn, Nicole R. Ledbetter, Christopher N. James, William D. Hoffman, Charlene R. Case, Guido F. Verbeck, and Kent D. Chapman
J. Biol. Chem. 2011 286: 3298-3306. First Published on November 30, 2010; doi:10.1074/jbc.M110.186353 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Ht31, a Protein Kinase A Anchoring Inhibitor, Induces Robust Cholesterol Efflux and Reverses Macrophage Foam Cell Formation through ATP-binding Cassette Transporter A1 Loretta Ma, Fumin Dong, Maxime Denis, Ying Feng, Ming-Dong Wang, and Xiaohui Zha
J. Biol. Chem. 2011 286: 3370-3378. First Published on November 24, 2010; doi:10.1074/jbc.M110.173666 [Abstract] [Full Text] [PDF] [Supplemental Data]  


Membrane Biology

 The NPC Motif of Aquaporin-11, Unlike the NPA Motif of Known Aquaporins, Is Essential for Full Expression of Molecular Function Masahiro Ikeda, Ayaka Andoo, Mariko Shimono, Natsuko Takamatsu, Asaka Taki, Kanako Muta, Wataru Matsushita, Tamayo Uechi, Toshiyuki Matsuzaki, Naoya Kenmochi, Kuniaki Takata, Sei Sasaki, Katsuaki Ito, and Kenichi Ishibashi
J. Biol. Chem. 2011 286: 3342-3350. First Published on November 30, 2010; doi:10.1074/jbc.M110.180968 [Abstract] [Full Text] [PDF]  

Hetero-oligomerization of Neuronal Glutamate Transporters Doreen Nothmann, Ariane Leinenweber, Delany Torres-Salazar, Peter Kovermann, Jasmin Hotzy, Armanda Gameiro, Christof Grewer, and Christoph Fahlke
J. Biol. Chem. 2011 286: 3935-3943. First Published on December 2, 2010; doi:10.1074/jbc.M110.187492 [Abstract] [Full Text] [PDF]  


Metabolism

 Disruption of the Acyl-CoA-binding Protein Gene Delays Hepatic Adaptation to Metabolic Changes at Weaning Ditte Neess, Maria Bloksgaard, Signe Bek, Ann-Britt Marcher, Ida C. Elle, Torben Helledie, Marianne Due, Vasileios Pagmantidis, Bente Finsen, Johannes Wilbertz, Mogens Kruhøffer, Nils Færgeman, and Susanne Mandrup
J. Biol. Chem. 2011 286: 3460-3472. First Published on November 24, 2010; doi:10.1074/jbc.M110.161109 [Abstract] [Full Text] [PDF]  

Genetic and Biochemical Analysis of High Iron Toxicity in Yeast: IRON TOXICITY IS DUE TO THE ACCUMULATION OF CYTOSOLIC IRON AND OCCURS UNDER BOTH AEROBIC AND ANAEROBIC CONDITIONS Huilan Lin, Liangtao Li, Xuan Jia, Diane McVey Ward, and Jerry Kaplan
J. Biol. Chem. 2011 286: 3851-3862. First Published on November 29, 2010; doi:10.1074/jbc.M110.190959 [Abstract] [Full Text] [PDF]  

Mitochondrial Dysfunction and Increased Reactive Oxygen Species Impair Insulin Secretion in Sphingomyelin Synthase 1-null Mice Masato Yano, Ken Watanabe, Tadashi Yamamoto, Kazutaka Ikeda, Takafumi Senokuchi, Meihong Lu, Tsuyoshi Kadomatsu, Hiroto Tsukano, Masahito Ikawa, Masaru Okabe, Shohei Yamaoka, Toshiro Okazaki, Hisanori Umehara, Tomomi Gotoh, Wen-Jie Song, Koichi Node, Ryo Taguchi, Kazuya Yamagata, and Yuichi Oike
J. Biol. Chem. 2011 286: 3992-4002. First Published on November 29, 2010; doi:10.1074/jbc.M110.179176 [Abstract] [Full Text] [PDF] [Supplemental Data]  


Microbiology

 Theoretical and Experimental Characterization of the Scope of Protein O-Glycosylation in Bacteroides fragilis C. Mark Fletcher, Michael J. Coyne, and Laurie E. Comstock
J. Biol. Chem. 2011 286: 3219-3226. First Published on November 29, 2010; doi:10.1074/jbc.M110.194506 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Induction of Caspase Activation and Cleavage of the Viral Nucleocapsid Protein in Different Cell Types during Crimean-Congo Hemorrhagic Fever Virus Infection Helen Karlberg, Yee-Joo Tan, and Ali Mirazimi
J. Biol. Chem. 2011 286: 3227-3234. First Published on December 1, 2010; doi:10.1074/jbc.M110.149369 [Abstract] [Full Text] [PDF]  

A Novel Mechanism of Osmosensing, a Salt-dependent Protein-Nucleic Acid Interaction in the Cyanobacterium Synechocystis Species PCC 6803 Jens F. Novak, Marit Stirnberg, Benjamin Roenneke, and Kay Marin
J. Biol. Chem. 2011 286: 3235-3241. First Published on December 1, 2010; doi:10.1074/jbc.M110.157032 [Abstract] [Full Text] [PDF] [Supplemental Data]  

In Vitro Selection and Characterization of HIV-1 Variants with Increased Resistance to Sifuvirtide, a Novel HIV-1 Fusion Inhibitor Zhonghua Liu, Mei Shan, Li Li, Lu Lu, Shu Meng, Cheng Chen, Yuxian He, Shibo Jiang, and Linqi Zhang
J. Biol. Chem. 2011 286: 3277-3287. First Published on November 23, 2010; doi:10.1074/jbc.M110.199323 [Abstract] [Full Text] [PDF]  

Differential Activities of Three Families of Specific β(1,3)Glucan Synthase Inhibitors in Wild-type and Resistant Strains of Fission Yeast Ivone M. Martins, Juan C. G. Cortés, Javier Muñoz, M. Belén Moreno, Mariona Ramos, José A. Clemente-Ramos, Angel Durán, and Juan C. Ribas
J. Biol. Chem. 2011 286: 3484-3496. First Published on November 29, 2010; doi:10.1074/jbc.M110.174300 [Abstract] [Full Text] [PDF]  

Expression of a Protein Phosphatase 1 Inhibitor, cdNIPP1, Increases CDK9 Threonine 186 Phosphorylation and Inhibits HIV-1 Transcription Tatiana Ammosova, Venkat R. K. Yedavalli, Xiaomei Niu, Marina Jerebtsova, Aleyde Van Eynde, Monique Beullens, Mathieu Bollen, Kuan-Teh Jeang, and Sergei Nekhai
J. Biol. Chem. 2011 286: 3798-3804. First Published on November 22, 2010; doi:10.1074/jbc.M110.196493 [Abstract] [Full Text] [PDF] [Supplemental Data]  


Molecular Bases of Disease

 Processing of Optineurin in Neuronal Cells Xiang Shen, Hongyu Ying, Ye Qiu, Jeong-Seok Park, Rajalekshmy Shyam, Zai-Long Chi, Takeshi Iwata, and Beatrice Y. J. T. Yue
J. Biol. Chem. 2011 286: 3618-3629. First Published on November 8, 2010; doi:10.1074/jbc.M110.175810 [Abstract] [Full Text] [PDF]  

The Apolipoprotein E-Mimetic Peptide COG112 Inhibits NF-B Signaling, Proinflammatory Cytokine Expression, and Disease Activity in Murine Models of Colitis Kshipra Singh, Rupesh Chaturvedi, Daniel P. Barry, Lori A. Coburn, Mohammad Asim, Nuruddeen D. Lewis, M. Blanca Piazuelo, M. Kay Washington, Michael P. Vitek, and Keith T. Wilson
J. Biol. Chem. 2011 286: 3839-3850. First Published on November 29, 2010; doi:10.1074/jbc.M110.176719 [Abstract] [Full Text] [PDF] [Supplemental Data]  


Molecular Biophysics

Atomic Force Microscopy Studies Provide Direct Evidence for Dimerization of the HIV Restriction Factor APOBEC3G Luda S. Shlyakhtenko, Alexander Y. Lushnikov, Ming Li, Lela Lackey, Reuben S. Harris, and Yuri L. Lyubchenko
J. Biol. Chem. 2011 286: 3387-3395. First Published on December 1, 2010; doi:10.1074/jbc.M110.195685 [Abstract] [Full Text] [PDF] [Supplemental Data] AUTHOR'S CHOICE  


Mechanism of Polyubiquitin Chain Recognition by the Human Ubiquitin Conjugating Enzyme Ube2g2 William E. Bocik, Aroop Sircar, Jeffrey J. Gray, and Joel R. Tolman
J. Biol. Chem. 2011 286: 3981-3991. First Published on November 22, 2010; doi:10.1074/jbc.M110.189050 [Abstract] [Full Text] [PDF] [Supplemental Data]  


Neurobiology

Activation of D1/D5 Dopamine Receptors Protects Neurons from Synapse Dysfunction Induced by Amyloid-β Oligomers Sofia Jürgensen, Leandro L. Antonio, Gabriela E. A. Mussi, Jordano Brito-Moreira, Theresa R. Bomfim, Fernanda G. De Felice, Emilio R. Garrido-Sanabria, Ésper A. Cavalheiro, and Sergio T. Ferreira
J. Biol. Chem. 2011 286: 3270-3276. First Published on November 29, 2010; doi:10.1074/jbc.M110.177790 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Packing of the Extracellular Domain Hydrophobic Core Has Evolved to Facilitate Pentameric Ligand-gated Ion Channel Function Cosma D. Dellisanti, Sonya M. Hanson, Lin Chen, and Cynthia Czajkowski
J. Biol. Chem. 2011 286: 3658-3670. First Published on November 22, 2010; doi:10.1074/jbc.M110.156851 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Amyloid-β Protein Oligomer at Low Nanomolar Concentrations Activates Microglia and Induces Microglial Neurotoxicity Izumi Maezawa, Pavel I. Zimin, Heike Wulff, and Lee-Way Jin
J. Biol. Chem. 2011 286: 3693-3706. First Published on October 22, 2010; doi:10.1074/jbc.M110.135244 [Abstract] [Full Text] [PDF] [Supplemental Data (.pdf, 3.4 MB)]  


Protein Structure and Folding

Aromatic Small Molecules Remodel Toxic Soluble Oligomers of Amyloid β through Three Independent Pathways Ali Reza A. Ladiwala, Jonathan S. Dordick, and Peter M. Tessier
J. Biol. Chem. 2011 286: 3209-3218. First Published on November 23, 2010; doi:10.1074/jbc.M110.173856 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Structural Determinants of Affinity Enhancement between GoLoco Motifs and G-Protein  Subunit Mutants Dustin E. Bosch, Adam J. Kimple, Deanne W. Sammond, Robin E. Muller, Michael J. Miley, Mischa Machius, Brian Kuhlman, Francis S. Willard, and David P. Siderovski
J. Biol. Chem. 2011 286: 3351-3358. First Published on November 29, 2010; doi:10.1074/jbc.M110.190496 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Insights into the Mechanism of Type I Dehydroquinate Dehydratases from Structures of Reaction Intermediates Samuel H. Light, George Minasov, Ludmilla Shuvalova, Mark-Eugene Duban, Michael Caffrey, Wayne F. Anderson, and Arnon Lavie
J. Biol. Chem. 2011 286: 3531-3539. First Published on November 18, 2010; doi:10.1074/jbc.M110.192831 [Abstract] [Full Text] [PDF]  

Biophysical Characterization of the Complex between Human Papillomavirus E6 Protein and Synapse-associated Protein 97 Celestine N. Chi, Anders Bach, Åke Engström, Kristian Strømgaard, Patrik Lundström, Neil Ferguson, and Per Jemth
J. Biol. Chem. 2011 286: 3597-3606. First Published on November 27, 2010; doi:10.1074/jbc.M110.190264 [Abstract] [Full Text] [PDF] [Author profile][Supplemental Data] [Summary]  

The Dimeric SOS Mutagenesis Protein UmuD Is Active as a Monomer Jaylene N. Ollivierre, Jacquelyn L. Sikora, and Penny J. Beuning
J. Biol. Chem. 2011 286: 3607-3617. First Published on November 29, 2010; doi:10.1074/jbc.M110.167254 [Abstract] [Full Text] [PDF]  

Crystal Structure of Heterodimeric Hexaprenyl Diphosphate Synthase from Micrococcus luteus B-P 26 Reveals That the Small Subunit Is Directly Involved in the Product Chain Length Regulation Daisuke Sasaki, Masahiro Fujihashi, Naomi Okuyama, Yukiko Kobayashi, Motoyoshi Noike, Tanetoshi Koyama, and Kunio Miki
J. Biol. Chem. 2011 286: 3729-3740. First Published on November 9, 2010; doi:10.1074/jbc.M110.147991 [Abstract] [Full Text] [PDF] [Supplemental Data (.jpg, 982 KB)]  

The Denatured State Dictates the Topology of Two Proteins with Almost Identical Sequence but Different Native Structure and Function Angela Morrone, Michelle E. McCully, Philip N. Bryan, Maurizio Brunori, Valerie Daggett, Stefano Gianni, and Carlo Travaglini-Allocatelli
J. Biol. Chem. 2011 286: 3863-3872. First Published on November 29, 2010; doi:10.1074/jbc.M110.155911 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Manganese Binds to Clostridium difficile Fbp68 and Is Essential for Fibronectin Binding Yi-Pin Lin, Chih-Jung Kuo, Xhelil Koleci, Sean P. McDonough, and Yung-Fu Chang
J. Biol. Chem. 2011 286: 3957-3969. First Published on November 9, 2010; doi:10.1074/jbc.M110.184523 [Abstract] [Full Text] [PDF] [Supplemental Figure 1. (.doc, 502 KB)]  


Protein Synthesis and Degradation

An Archaeal tRNA-Synthetase Complex that Enhances Aminoacylation under Extreme Conditions Vlatka Godinic-Mikulcic, Jelena Jaric, Corinne D. Hausmann, Michael Ibba, and Ivana Weygand-Durasevic
J. Biol. Chem. 2011 286: 3396-3404. First Published on November 22, 2010; doi:10.1074/jbc.M110.168526 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Liver Cytochrome P450 3A Endoplasmic Reticulum-associated Degradation: A MAJOR ROLE FOR THE p97 AAA ATPase IN CYTOCHROME P450 3A EXTRACTION INTO THE CYTOSOL Poulomi Acharya, Mingxiang Liao, Juan C. Engel, and Maria Almira Correia
J. Biol. Chem. 2011 286: 3815-3828. First Published on November 24, 2010; doi:10.1074/jbc.M110.186981 [Abstract] [Full Text] [PDF] [Supplemental Data]  


RNA

 Regulation of Heme Oxygenase-1 Protein Expression by miR-377 in Combination with miR-217 Joan D. Beckman, Chunseng Chen, Julia Nguyen, Venugopal Thayanithy, Subbaya Subramanian, Clifford J. Steer, and Gregory M. Vercellotti
J. Biol. Chem. 2011 286: 3194-3202. First Published on November 24, 2010; doi:10.1074/jbc.M110.148726 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Recognition of Transcription Termination Signal by the Nuclear Polyadenylated RNA-binding (NAB) 3 Protein Fruzsina Hobor, Roberto Pergoli, Karel Kubicek, Dominika Hrossova, Veronika Bacikova, Michal Zimmermann, Josef Pasulka, Ctirad Hofr, Stepanka Vanacova, and Richard Stefl
J. Biol. Chem. 2011 286: 3645-3657. First Published on November 17, 2010; doi:10.1074/jbc.M110.158774 [Abstract] [Full Text] [PDF] AUTHOR'S CHOICE  

Signal Transduction

Allosteric Modulation of Ras-GTP Is Linked to Signal Transduction through RAF Kinase Greg Buhrman, V. S. Senthil Kumar, Murat Cirit, Jason M. Haugh, and Carla Mattos
J. Biol. Chem. 2011 286: 3323-3331. First Published on November 22, 2010; doi:10.1074/jbc.M110.193854 [Abstract] [Full Text] [PDF]  

Transactivation of the Epidermal Growth Factor Receptor by Heat Shock Protein 90 via Toll-like Receptor 4 Contributes to the Migration of Glioblastoma Cells Dominique Thuringer, Arlette Hammann, Naïma Benikhlef, Eric Fourmaux, André Bouchot, Guillaume Wettstein, Eric Solary, and Carmen Garrido
J. Biol. Chem. 2011 286: 3418-3428. First Published on December 2, 2010; doi:10.1074/jbc.M110.154823 [Abstract] [Full Text] [PDF] [Supplemental Data]  

SNF1-related Protein Kinases 2 Are Negatively Regulated by a Plant-specific Calcium Sensor Maria Bucholc, Arkadiusz Ciesielski, Grazyna Goch, Anna Anielska-Mazur, Anna Kulik, Ewa Krzywinska, and Grazyna Dobrowolska
J. Biol. Chem. 2011 286: 3429-3441. First Published on November 22, 2010; doi:10.1074/jbc.M110.115535 [Abstract] [Full Text] [PDF] [Supplemental Data]  

PTB-associated Splicing Factor (PSF) Functions as a Repressor of STAT6-mediated Ig Gene Transcription by Recruitment of HDAC1 Lijie Dong, Xinyu Zhang, Xiao Fu, Xianzhi Zhang, Xingjie Gao, Mengyu Zhu, Xinting Wang, ZhenXia Yang, Ole Nørregaard Jensen, Juha Saarikettu, Zhi Yao, Olli Silvennoinen, and Jie Yang
J. Biol. Chem. 2011 286: 3451-3459. First Published on November 24, 2010; doi:10.1074/jbc.M110.168377 [Abstract] [Full Text] [PDF]  

FcRIIIb Triggers Raft-dependent Calcium Influx in IgG-mediated Responses in Human Neutrophils Louis Marois, Guillaume Paré, Myriam Vaillancourt, Emmanuelle Rollet-Labelle, and Paul H. Naccache
J. Biol. Chem. 2011 286: 3509-3519. First Published on December 1, 2010; doi:10.1074/jbc.M110.169516 [Abstract] [Full Text] [PDF]  

Pigment Epithelium-derived Factor and Its Phosphomimetic Mutant Induce JNK-dependent Apoptosis and p38-mediated Migration Arrest Alexander Konson, Sunila Pradeep, Cosimo Walter D'Acunto, and Rony Seger
J. Biol. Chem. 2011 286: 3540-3551. First Published on November 8, 2010; doi:10.1074/jbc.M110.151548 [Abstract] [Full Text] [PDF] [Appears within the pdf file (.pdf, 8.1 MB)]  

Arrestin-2 Differentially Regulates PAR4 and ADP Receptor Signaling in Platelets Dongjun Li, Lauren D'Angelo, Massiel Chavez, and Donna S. Woulfe
J. Biol. Chem. 2011 286: 3805-3814. First Published on November 24, 2010; doi:10.1074/jbc.M110.118018 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Kinetic Studies of the Arf Activator Arno on Model Membranes in the Presence of Arf Effectors Suggest Control by a Positive Feedback Loop Danièle Stalder, Hélène Barelli, Romain Gautier, Eric Macia, Catherine L. Jackson, and Bruno Antonny
J. Biol. Chem. 2011 286: 3873-3883. First Published on November 30, 2010; doi:10.1074/jbc.M110.145532 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Small Ubiquitin-like Modifier Modification of Arrestin-3 Regulates Receptor Trafficking Debra Wyatt, Rohit Malik, Alissa C. Vesecky, and Adriano Marchese
J. Biol. Chem. 2011 286: 3884-3893. First Published on November 30, 2010; doi:10.1074/jbc.M110.152116 [Abstract] [Full Text] [PDF] [Supplemental Data]  

Deactivation of STAT6 through Serine 707 Phosphorylation by JNK Takashi Shirakawa, Yoshinori Kawazoe, Tomoko Tsujikawa, Dongju Jung, Shin-ichi Sato, and Motonari Uesugi
J. Biol. Chem. 2011 286: 4003-4010. First Published on December 1, 2010; doi:10.1074/jbc.M110.168435 [Abstract] [Full Text] [PDF] [Supplemental Data]

  
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